1. Instituto Nacional de Pediatría
2. INP
3. Artículos Investigadores

Título :	Use of in vitro assays to assess the potential antigenotoxic and cytotoxic effects of saffron. (Crocus sativus L.)
Creador:	FIKRAT ABDULLAEV JAFAROVA LETICIA RIVERON NEGRETE HERIBERTO CABALLERO ORTEGA JUAN MANUEL HERNANDEZ LOPEZ ELEAZAR ISRAEL PEREZ LOPEZ ROGELIO GREGORIO PEREDA MIRANDA JESUS JAVIER ESPINOSA AGUIRRE
Nivel de acceso:	Acceso Abierto
Palabras clave :	MEDICINA Y CIENCIAS DE LA SALUD Antimutagénicos - Toxicidad Supervivencia celular - Efectos de drogas Crocus - Toxicidad Pruebas de mutagenicidad - Métodos Extractos vegetales - Toxicidad Salmonella typhimurium - Genética Células madre - Efectos de drogas Antimutagenic agents - Toxicity Cell Survival - Drug effects Crocus - Toxicity Mutagenicity tests - Methods Plant Extracts - Toxicity Salmonella typhimurium - Genetics Stem Cells - Drug effects Azafrán Crocus sativus Citotoxicidad Mutagenicidad Co-mutagenicidad Saffron Crocus sativus Cytotoxicity Mutagenicity Co-mutagenicity
Descripción :	Saffron is harvested from the dried, dark red stigmas of Crocus sativus L. flowers. It is used as a spice for flavoring and coloring food and as a perfume. It is often used for treating several diseases. We assessed the antimutagenic, comutagenic and cytotoxic effects of saffron and its main ingredients using the Ames/Salmonella test system, two well known mutagens (BP, 2AA), the in vitro colony formation assay and four different cultured human normal (CCD-18Lu) and malignant (HeLa, A-204 and HepG2) cells. When only using the TA98 strain in the Ames/Salmonella test system, saffron showed non-mutagenic, as well as non-antimutagenic activity against BP-induced mutagenicity, and demonstrated a dose-dependent co-mutagenic effect on 2-AA-induced mutagenicity. The saffron component responsible for this unusual comutagenic effect was safranal. In the in vitro colony formation test system, saffron displayed a dose-dependent inhibitory effect only against human malignant cells. All isolated carotenoid ingredients of saffron demonstrated cytotoxic activity against in vitro tumor cells. Saffron crocin derivatives possessed a stronger inhibitory effect on tumor cell colony formation. Overall, these results suggest that saffron itself, as well as its carotenoid components might be used as potential cancer chemopreventive agents. © 2003 Elsevier Ltd. All rights reserved.
Editorial :	Pergamon Press
Fecha de publicación :	2003
Tipo de publicación:	Artículo
Formato:	Adobe PDF
Identificador del Recurso :	10.1016/S0887-2333(03)00098-5
Fuente:	Toxicology in Vitro 17(5 y 6):731-736
URI :	http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/3112
Aparece en las colecciones:	Artículos Investigadores

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