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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2943| Título : | Use of in vitro assays to assess the potential antigenotoxic and cytotoxic effects of saffron (Crocus sativus L.) |
| Creador: | Abdullaev FI |
| Nivel de acceso: | Open access |
| Palabras clave : | Antimutagênicos - toxicidad Supervivencia Celular - efectos de drogas Crocus - toxicidad Pruebas de Mutagenicidad - métodos Extractos Vegetales - toxicidad Salmonella typhimurium - genética Células Madre - efectos de drogas Antimutagenic Agents - toxicity Cell Survival - drug effects Crocus - toxicity Mutagenicity Tests - methods Plant Extracts - toxicity Salmonella typhimurium - genetics Stem Cells - drug effects Azafrán Crocus sativus Citotoxicidad Mutagenicidad Co-mutagenicidad Saffron Crocus sativus Cytotoxicity Mutagenicity Co-mutagenicity |
| Descripción : | Saffron is harvested from the dried, dark red stigmas of Crocus sativus L. flowers. It is used as a spice for flavoring and coloring food and as a perfume. It is often used for treating several diseases. We assessed the antimutagenic, comutagenic and cytotoxic effects of saffron and its main ingredients using the Ames/Salmonella test system, two well known mutagens (BP, 2AA), the in vitro colony formation assay and four different cultured human normal (CCD-18Lu) and malignant (HeLa, A-204 and HepG2) cells. When only using the TA98 strain in the Ames/Salmonella test system, saffron showed non-mutagenic, as well as non-antimutagenic activity against BP-induced mutagenicity, and demonstrated a dose-dependent co-mutagenic effect on 2-AA-induced mutagenicity. The saffron component responsible for this unusual comutagenic effect was safranal. In the in vitro colony formation test system, saffron displayed a dose-dependent inhibitory effect only against human malignant cells. All isolated carotenoid ingredients of saffron demonstrated cytotoxic activity against in vitro tumor cells. Saffron crocin derivatives possessed a stronger inhibitory effect on tumor cell colony formation. Overall, these results suggest that saffron itself, as well as its carotenoid components might be used as potential cancer chemopreventive agents. © 2003 Elsevier Ltd. All rights reserved. |
| Colaborador(es) u otros Autores: | Riverón Negrete L Caballero Ortega H Manuel Hernández J Pérez López I Pereda Miranda R Espinosa Aguirre JJ |
| Fecha de publicación : | 2003 |
| Tipo de publicación: | Otros |
| Formato: | |
| Identificador del Recurso : | 10.1016/S0887-2333(03)00098-5 |
| Fuente: | Toxicology in Vitro 17(5 y 6):731-736 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2943 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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