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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2942| Título : | Allergy and acute leukaemia in children with Down syndrome: a population study. Report from the Mexican inter-institutional group for the identification of the causes of childhood leukaemia |
| Creador: | Núñez Eníquez J.C., |
| Nivel de acceso: | Open access |
| Palabras clave : | Estudios de Casos y Controles Niño Síndrome de Down - epidemiología Femenino Humanos Hipersensibilidad - epidemiología Modelos Logísticos Masculino México Leucemia-Linfoma Linfoblástico de Células Precursoras - epidemiología Case-Control Studies Child Down Syndrome - epidemiology Female Humans Hypersensitivity - epidemiology Logistic Models Male Mexico Precursor Cell Lymphoblastic Leukemia-Lymphoma - epidemiology Leucemia linfoblástica aguda Trisomía 21 Alergia Niño epidemiología acute lymphoblastic leukaemia Down syndrome allergy children epidemiology |
| Descripción : | Background:Allergies have been described as protective factors against the development of childhood acute leukaemia (AL). Our objective was to investigate the associations between allergy history and the development of AL and acute lymphoblastic leukaemia (ALL) in children with Down syndrome (DS).Methods:A case–control study was performed in Mexico City. The cases (n=97) were diagnosed at nine public hospitals, and the controls (n=222) were recruited at institutions for children with DS. Odds ratios (OR) were calculated.Results:Asthma was positively associated with AL development (OR=4.18; 95% confidence interval (CI): 1.47–11.87), whereas skin allergies were negatively associated (OR=0.42; 95% CI: 0.20–0.91).Conclusion:Our findings suggest that allergies and AL in children with DS share biological and immune mechanisms. To our knowledge, this is the first study reporting associations between allergies and AL in children with DS. © 2013 Cancer Research UK. All rights reserved. |
| Colaborador(es) u otros Autores: | Fajardo-Gutiérrez A. Buchán-Durán E.P. Bernáldez-Ríos R. Medina-Sansón A. Jiménez-Hernández E. Amador-Sanchez R. Peñaloza-Gonzalez J.G. Paredes-Aguilera R. Alvarez-Rodriguez F.J. Bolea-Murga V. de Diego Flores-Chapa J. Flores-Lujano J. Bekker-Mendez V.C. Rivera-Luna R. del Carmen Rodriguez-Zepeda M. Rangel-López A. Dorantes-Acosta E.M. Núñez-Villegas N. Velazquez-Avila M.M. Torres-Nava J.R. Reyes-Zepeda N.C. Cárdenas-Cardos R. Flores-Villegas L.V. Martinez-Avalos A. Salamanca-Gómez F. Gorodezky C. Arellano-Galindo J. Mejía-Aranguré J.M. |
| Fecha de publicación : | 2013 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1038/bjc.2013.237 |
| Fuente: | British Journal of Cancer 108(11):2334 - 2338 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2942 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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