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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2913| Título : | Tissue-specific induction of the carcinogen-inducible cytochrome P450 isoforms in the gastrointestinal tract |
| Creador: | Nancy Hernandez Martınez |
| Nivel de acceso: | Open access |
| Palabras clave : | Esteroide 17-alfa-Hidroxilasa - farmacología - ratas Esteroide 17-alfa-Hidroxilasa - efecto de drogas - ratas Esteroide 17-alfa-Hidroxilasa - toxicidad - ratas Inducción Enzimática - efecto de drogas - ratas Tracto Gastrointestinal - anatomía & histología - ratas Tracto Gastrointestinal - enzimología - ratas Fenobarbital - uso terapéutico - ratas Ratas Wistar Steroid 17-alpha-Hydroxylase - pharmacology - rats Steroid 17-alpha-Hydroxylase - drug effects - rats Steroid 17-alpha-Hydroxylase - toxicity - rats Enzyme Induction - drug effects - rats Gastrointestinal Tract - anatomy & histology - rats Gastrointestinal Tract - enzymology - rats Phenobarbital - therpeutic use - rats Rats, Wistar Cytochrome P450 Gastrointestinal tract Inducers |
| Descripción : | Gastrointestinal tissues are directly exposed to dietary xenobiotics. In spite of this, modulation of cytochrome P450 (CYP) enzymes in the gastrointestinal tract is not well established. CYP induction could facilitate transformation of chemical agents to potentially toxic or carcinogenic metabolites. This might also determine drug efficacy, burden of foreign chemicals on tissues or bioavailability of certain therapeutic agents. In order to assess the induction of the CYP subfamilies 1A1/2, 2B1/2, 2E1 and 3A2 in the gastrointestinal tract, male Wistar rats were treated with phenobarbital/β-naphthoflavone (PB/NF), cyclohexanol/albendazole (CH/ABZ) or toluene (TL). Microsomal fractions were prepared from tissue samples of the esophagus, the stomach, the duodenum, the colon and the liver. Western blot and enzymatic activity analyses revealed an increase in the expression and activity of CYP1A1/2 and CYP3A2 isoenzymes in the esophageal, duodenal and colonic microsomes from animals treated with PB/NF. CYP1A1/2 and CYP3A2 were induced in hepatic and duodenum microsomes by treatment with CH/ABZ. Our results demonstrate differential induction of CYP along the gastrointestinal tract by known CYP hepatic inducers, being the treatment with PB/NF the best induction system of the CYPs. © 2007 Elsevier B.V. All rights reserved. |
| Colaborador(es) u otros Autores: | Heriberto Caballero-Ortega Víctor Dorado-Gonzalez Norma Labra-Ruiz Jesus Javier Espinosa-Aguirre Josefina Gomez-Garduño Araceli Vences-Mejıa |
| Fecha de publicación : | 2007 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1016/j.etap.2007.07.004 |
| Fuente: | Environmental Toxicology and Pharmacology 24(3):297 - 303 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2913 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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