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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2898| Título : | Air pollution: mechanisms of neuroinflammation and CNS disease |
| Creador: | Block M.L., |
| Nivel de acceso: | Open access |
| Palabras clave : | Contaminación del Aire - Toxicidad Contaminación del Aire Barrera Hematoencefálica - patología Enfermedades del Sistema Nervioso Central - inducido químicamente Enfermedades del Sistema Nervioso Central - clasificación Enfermedades del Sistema Nervioso Central - patología Humanos Inflamación - inducido químicamente Inflamación - patología Neuroglía - patología Especies Reactivas de Oxígeno - metabolismo Air Pollutants/toxicity Air Pollution Blood-Brain Barrier - pathology Central Nervous System Diseases - chemically induced Central Nervous System Diseases - classification Central Nervous System Diseases - pathology Humans Inflammation - chemically induced Inflammation - pathology Neuroglia - pathology Reactive Oxygen Species - metabolism Contaminación del aire Neuroinflamación Enfermedades del Sistema Nervioso Central Air pollution Neuroinflammation Central Nervous System Diseases |
| Descripción : | Air pollution has been implicated as a chronic source of neuroinflammation and reactive oxygen species (ROS) that produce neuropathology and central nervous system (CNS) disease. Stroke incidence and Alzheimer's and Parkinson's disease pathology are linked to air pollution. Recent reports reveal that air pollution components reach the brain; systemic effects that impact lung and cardiovascular disease also impinge upon CNS health. While mechanisms driving air pollution-induced CNS pathology are poorly understood, new evidence suggests that microglial activation and changes in the blood-brain barrier are key components. Here we summarize recent findings detailing the mechanisms through which air pollution reaches the brain and activates the resident innate immune response to become a chronic source of pro-inflammatory factors and ROS, culminating in CNS disease. © 2009 Elsevier Ltd. All rights reserved. |
| Colaborador(es) u otros Autores: | Calderón-Garcidueñas L. |
| Fecha de publicación : | 2009 |
| Tipo de publicación: | Revisión |
| Formato: | |
| Identificador del Recurso : | 10.1016/j.tins.2009.05.009 |
| Fuente: | Trends in Neurosciences 32(9):506 - 516 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2898 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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