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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2853| Título : | Air pollution and brain damage |
| Creador: | Calderón Garcidueñas, Lilian |
| Nivel de acceso: | Open access |
| Palabras clave : | Contaminantes del aire - efectos adversos Apoptosis Barrera Hematoencefálica Encefalopatías - inducido químicamente Encefalopatías - etiología Corteza cerebral - efectos de drogas Pulmón - efectos de drogas México Bulbo Olfatorio - efectos de drogas Air Pollutants - adverse effects Apoptosis Blood-Brain Barrier Brain Diseases - chemically induced Brain Diseases - etiology Cerebral Cortex - drug effects Lung - drug effects Mexico Olfactory Bulb - drug effects Contaminación del aire México Caninos alzheimer epitelio BBB NFjB iNOSnasal Air pollution Mexico City canines Alzheimer’s nasal epithelia BBB NFjB iNOS. |
| Descripción : | Exposure to complex mixtures of air pollutants produces inflammation in the upper and lower respiratory tract. Because the nasal cavity is a common portal of entry, respiratory and olfactory epithelia are vulnerable targets for toxicological damage. This study has evaluated, by light and electron microscopy and immunohistochemical expression of nuclear factor-kappa beta (NF-kappaB) and inducible nitric oxide synthase (iNOS), the olfactory and respiratory nasal mucosae, olfactory bulb, and cortical and subcortical structures from 32 healthy mongrel canine residents in Southwest Metropolitan Mexico City (SWMMC), a highly polluted urban region. Findings were compared to those in 8 dogs from Tlaxcala, a less polluted, control city. In SWMMC dogs, expression of nuclear neuronal NF-kappaB and iNOS in cortical endothelial cells occurred at ages 2 and 4 weeks; subsequent damage included alterations of the blood-brain barrier (BBB), degenerating cortical neurons, apoptotic glial white matter cells, deposition of apolipoprotein E (apoE)-positive lipid droplets in smooth muscle cells and pericytes, nonneuritic plaques, and neurofibrillary tangles. Persistent pulmonary inflammation and deteriorating olfactory and respiratory barriers may play a role in the neuropathology observed in the brains of these highly exposed canines. Neurodegenerative disorders such as Alzheimer's may begin early in life with air pollutants playing a crucial role. |
| Colaborador(es) u otros Autores: | Azzarelli B Acuna H Garcia R Gambling TM Osnaya N Monroy S del Tizapantzi MR Carson JL Villarreal-Calderon A Rewcastle B. |
| Fecha de publicación : | 2002 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Fuente: | Toxicol Pathol 30(3):373-89. |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2853 |
| Idioma: | spa |
| Aparece en las colecciones: | Artículos |
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