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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2848| Título : | Susceptibility of Mexican isolates of yeasts and moulds to amphotericin B and triazole antifungals |
| Creador: | Arredondo García, José Luis |
| Nivel de acceso: | Open access |
| Palabras clave : | Anfotericina B - farmacologia - humans - México Antifúngicos - farmacologia - humans - México Farmacorresistencia Fúngica - humans - México Hongos - clasificación - humans - México Hongos - efectos de drogas - humans - México Hongos - aislamiento & purificación - humans - México Pruebas de Sensibilidad Microbiana - humans - México Micosis - microbiologia - humans - México Triazoles - farmacologia - humans - México Población Urbana Amphotericin B - pharmacology - humans - Mexico Antifungal Agents - pharmacology - humans - Mexico Drug Resistance, Fungal - humans - Mexico Fungi - classification - humans - Mexico Fungi - drug effects - humans - Mexico Fungi - isolation & purification - humans - Mexico Microbial Sensitivity Tests - - humans - Mexico Mycoses - microbiology - humans - Mexico Triazoles - pharmacology - humans - Mexico Urban Population Candida spp, moldes, susceptibilidad in vitro, azoles, anfotericina B Candida spp., moulds, in vitro susceptibility, azoles, amphotericin B |
| Descripción : | Background: Resistance to antifungal drugs, especially towards triazoles, is commonly referred to by clinicians, but data on its prevalence in developing countries is limited. Methodology: To determine the prevalence of triazole-resistance amongst pathogenic yeasts and moulds, we assessed the in vitro susceptibility of 250 isolates from hospitalized patients at five Mexican cities towards amphotericin B, fluconazole and voriconazole, by E-test. Results: All yeasts were susceptible to voriconazole, according to E-test interpretive criteria (MIC ≤ 1 μg/mL), and all filamentous or dimorphic fungi also had voriconazole MIC ≤ 1 μg/mL, except for one isolate each of Mucor sp. and Acremonium sp. Candida krusei and one isolate of C. glabrata were resistant to fluconazole, a drug that had MIC ≤ 192 μg/mL for filamentous fungi. Although no breakpoints for amphotericin B are available, all three C. krusei, 2/25 C. glabrata, 3/ 22 C. parapsilosis and 1/108 C. albicans had MIC ≤ 2 μg/mL. Conclusion: In vitro, voriconazole is active against yeasts and moulds commonly causing severe mycoses in Mexico. Copyright © 2009 Arredondo-Garcia et al. |
| Colaborador(es) u otros Autores: | Amábile-Cuevas CF |
| Fecha de publicación : | 2009 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Fuente: | Journal of Infection in Developing Countries 3(5):398 - 401 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2848 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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