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Título : Serotonin and 5-hydroxy-indole-acetic acid contents in dorsal raphe and suprachiasmatic nuclei in normal, malnourished and rehabilitated rats under 24 h of sleep deprivation
Creador: Alfaro Rodríguez A
Nivel de acceso: Open access
Palabras clave : Conducta Animal - Ratas
Cromatografía Líquida de Alta Presión - métodos - Ratas
Ácido Hidroxiindolacético - metabolismo - Ratas
Desnutrición - metabolismo - Ratas
Desnutrición - patología - Ratas
Desnutrición - rehabilitación - Ratas
Núcleos del Rafe - metabolismo - Ratas
Sprague-Dawley - Ratas
Serotonina - metabolismo - Ratas
Privación de Sueño - metabolismo - Ratas
Núcleo Supraquiasmático - metabolismo - Ratas
Behavior, Animal - Rats
Chromatography, High Pressure Liquid - methods - Rats
Hydroxyindoleacetic Acid - metabolism - Rats
Malnutrition - metabolism - Rats
Malnutrition - pathology - Rats
Malnutrition - rehabilitation - Rats
Raphe Nuclei metabolism - Rats
Rats, Sprague-Dawley - Rats
Serotonin - metabolism - Rats
Sleep Deprivation - metabolism - Rats
Suprachiasmatic Nucleus - metabolism - Rats
Serotonina
ácido 5-hidroxi-indol-acético
Dorsal núcleos del rafe
núcleo supraquiasmático
Desnutrición
Privación del sueño, ratas
Serotonin
5-Hydroxy-indole-acetic acid
Dorsal raphe nuclei
Suprachiasmatic nuclei
Malnutrition
Sleep deprivation, rats
Descripción : It has been discussed that serotonin (5-HT) could be involved in the effects of sleep deprivation (SD) and/or malnutrition (M) on the sleep-wake cycle. The aim of this work was to study the effects of the M, SD and its interaction on 5-HT and 5-hydroxy-indole-acetic acid (5-HIAA) contents in the dorsal raphe (DR) and the suprachiasmatic nuclei (SCN), two sleep-wake cycle regulators. Forty-eight puppets rats were obtained from mothers fed with low or normal casein diet. They were allocated in 3 groups (n = 16 each): prenatal/postnatal casein malnutrition (6/6%), prenatal casein malnutrition/nutritional casein rehabilitation (6/25%) and prenatal/postnatal casein well-nourished state (25/25%). When rats were 60 days old, 24 animals were exposed to sleep deprivation by means of forced locomotion during 24 h. The remaining 24 were kept under normal conditions of sleep-wake cycle. Then, all animals were sacrificed by decapitation. DR and SCN were dissected and processed to determine the 5-HT and 5-HIAA contents by means of HPLC. It was observed that 6/6% rats showed a 5-HT increase (DR p < 0.011; SCN p < 0.019) as well as in SD (DR p < 0.0008; SCN p < 0.0009) with respect to 25/25% rats. No differences were found in 6/25% rats. Therefore, 5-HIAA decreased significantly in both nuclei in all the groups, notably in M + SD animals (DR p < 0.001; SCN p < 0.001). We conclude that the sleep-wake cycle disruptions produced by chronic M and SD are mediated in part by a synergistic effect on 5-HT in the DR-SCN pathway, perhaps due to a delay in the development of such brain structures. © 2006 Elsevier B.V. All rights reserved.
Colaborador(es) u otros Autores: Gonzalez Piña R
Gonzalez Maciel A
Arch Tirado E.
Fecha de publicación : 2006
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1016/j.brainres.2006.06.069
Fuente: Brain Research 1110(1):95 - 101
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2800
Idioma: eng
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