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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2766| Título : | Reliable method for the determination of ranitidine by liquid chromatography using a microvolume of plasma |
| Creador: | Flores Pérez, Carmen |
| Nivel de acceso: | Open access |
| Palabras clave : | Cromatografía Líquida de Alta Presión - métodos Antagonistas de los Receptores Histamínicos H2 - sangre Ranitidina - sangre Reproducibilidad de Resultados Espectrofotometría Ultravioleta - métodos Chromatography, High Pressure Liquid - methods Histamine H2 Antagonist - blood Ranitidine - blood Reproducibility of Results Spectrophotometry, Ultraviolet - methods Ranitidina Ranitidine |
| Descripción : | The aim of the present study was to develop a simple method to measure ranitidine, using 100 μl of plasma, by high-performance liquid chromatography with a Symmetry C18 column and UV detection at 313 nm. Linearity was assessed in the range from 50 to 1500 ng ml-1 and had a correlation coefficient of 0.999. The inter- and intra-day coefficients of variation were less than 7%. The limits of detection and quantitation were 5 and 15 ng ml-1, respectively. Drug levels were determined satisfactorily in three patients. A simple and reliable method was developed which uses a microvolume of plasma, particularly useful in low-weight children. © 2003 Elsevier B.V. All rights reserved. |
| Colaborador(es) u otros Autores: | Juárez Olguín H Flores Pérez J Toledo López A Lares Asseff I Alvarez García C |
| Fecha de publicación : | 2003 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1016/S1570-0232(03)00474-4 |
| Fuente: | Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 795(1):141 - 144 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2766 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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