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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2764| Título : | Adverse Effects of Imipramine are Increased by Interaction with ASA in Depressed Patients |
| Creador: | Juárez Olguín, Mateo Hugo |
| Nivel de acceso: | Open access |
| Palabras clave : | Imipramina - análisis Imipramina - efectos adversos Imipramina - sangre Imipramina - uso terapéutico Aspirina - uso terapéutico Aspirina - análisis Proteínas Portadoras - farmacocinética Antidepresivos - farmacología Imipramine - analysis Imipramine - Adverse Effects Imipramine - blood Imipramine - therapeutic use Aspirin - therpeutic use Aspirin- analysis Carrier Proteins - pharmacokinetics Antidepressive Agents - pharmacology Imipramina efectos adversos pacientes con depresión Imipramine Adverse Effects Depressed Patients |
| Descripción : | Because protein binding is a process that can be changed by the presence of other drugs with similar or greater affinity for proteins than the original compound, this causes a greater concentration of the free drug, while potentializing adverse effects, the most important factor responsible for noncompliance (Demyttenaere 1997; Fincke et al. 1998). The purpose of this study was to measure the binding of imipramine to plasma proteins when administered simultaneously with acetyl salicylic acid (ASA). Such interaction would be more clearly defined using clinical assessment parameters in patients treated with imipramine, who additionally need the second drug. The study was carried out in 20 clinically diagnosed depressed patients (16 F, 4 M, average age 38.3 6 13.3 years and weight 63.8 6 9.0 kg) to which imipramine (Tofranil) was administered at doses of 75 mg every 12 h. Informed consent was obtained for all patients before the study. |
| Colaborador(es) u otros Autores: | Jung-Cook Helgi Flores Pérez Janett Lares-Asseff Ismael |
| Fecha de publicación : | 2000 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1016/S0893-133X(99)00087-1 |
| Fuente: | Neuropsychopharmacol 22(1):100-101 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2764 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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