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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2748| Título : | Pyridoxine, regardless of serotonin levels, increases production of 5-hydroxytryptophan in rat brain |
| Creador: | Calderón Guzmán, David |
| Nivel de acceso: | Open access |
| Palabras clave : | 5-Hidroxitriptófano - Metabolismo Antioxidantes - Química Antioxidantes - Farmacología Encéfalo - Efecto de drogas 5-Hydroxytryptophan - Metabolism Antioxidants - Chemistry Antioxidants - Pharmacology Brain - Drug effects Aminas biogénicas Cerebro Peroxidación de lípidos Pyridoxine Serotonina Vitaminas. Biogenic amines Brain Lipid peroxidation Pyridoxine Serotonin Vitamins. |
| Descripción : | Background The aim of this study was to evaluate effects of pyridoxine and butylated hydroxytoluene (BHT) on lipid peroxidation and on levels of 5-hydroxytryptophan and serotonin. Methods Thirty rats (30 days of age) were used in the survey, measuring levels of lipid peroxidation (TBARS), hemoglobin, 5-hydroxytryptophan (5-HTP), and serotonin (5-HT) after intraperitoneal (i.p.) injections of 4 and 10 mg/kg/day of pyridoxine HCl during 20 days and a single dose of 2 μM/kg (440 μg) of BHT. Results Levels of TBARS and 5-HTP increased considerably (p <0.05) in all vitamin- and/or BHT-treated groups, and 5-HT increased partially (p <0.05) only in B6 with or without BHT-treated groups compared with control group. Conclusions Results suggest that pyridoxine plays a role in tryptophan metabolism, increasing production of 5-HTP. © 2004 IMSS. Published by Elsevier Inc. |
| Colaborador(es) u otros Autores: | Hernandez Islas Jose Luis Espitia Vazquez Ivonne Barragan Mejıa Gerardo Hernandez Garcıa Ernestina Santamarıa del Angel Daniel Juarez Olguín Hugo |
| Fecha de publicación : | 2004 |
| Tipo de publicación: | Revisión |
| Formato: | |
| Identificador del Recurso : | 10.1016/j.arcmed.2004.03.003 |
| Fuente: | Archives of Medical Research 35(4):271 - 274 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2748 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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