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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2729| Título : | Progress in Neuroprotective Strategies for Preventing Epilepsy |
| Creador: | Munjal M. Acharya |
| Nivel de acceso: | Open access |
| Palabras clave : | Animales Anticonvulsivantes - clasificación Anticonvulsivantes - uso terapéutico Encéfalo - citología Encéfalo - Fisiopatología Enfermedad crónica Dietoterapia - métodos Dieta Baja en Carbohidratos Epilepsia del Lóbulo Temporal - quimioterapia Epilepsia del Lóbulo Temporal - prevención & control Humanos Cuerpos Cetónicos - Metabolismo Neuronas - Clasificación Neuronas - citología Fármacos Neuroprotectores - clasificación Fármacos Neuroprotectores - terapéutica de uso Animals Anticonvulsants - classification Anticonvulsants - therapeutic use Brain - cytology Brain - physiopathology Chronic Disease Diet Therapy - methods Diet, Carbohydrate-Restricted Epilepsy, Temporal Lobe - drug therapy Epilepsy, Temporal Lobe - prevention & control Humans Ketone Bodies - metabolism Neurons - classification Neurons - cytology Neuroprotective Agents - classification Neuroprotective Agents - therapeutic use "reorganización sináptica aberrante; drogas antiepilépticas; antioxidantes; giro dentado; dentado neurogénesis; Interneuronas GABA-ergic; lesión en la cabeza; hipocampo; injertos de células hipocampales; hormonas; dieta cetogénica; aprendizaje y déficit de memoria; Fibra musgosa de brotación; células neuronales trasplantes; células madre neurales; neurodegeneración; factores neurotróficos; crisis convulsivas espontáneas; Estado epiléptico; plasticidad sináptica; epilepsia del lóbulo temporal" aberrant synaptic reorganization; antiepileptic drugs; antioxidants; dentate gyrus; dentate neurogenesis; GABA-ergic interneurons; head injury; hippocampus; hippocampal cell grafts; hormones; ketogenic diet; learning and memory deficits; mossy fiber sprouting; neural cell transplants; neural stem cells; neurodegeneration; neurotrophic factors; spontaneous seizures; status epilepticus; synaptic plasticity; temporal lobe epilepsy |
| Descripción : | Neuroprotection is increasingly considered as a promising therapy for preventing and treating temporal lobe epilepsy (TLE). The development of chronic TLE, also termed as epileptogenesis, is a dynamic process. An initial precipitating injury (IPI) such as the status epilepticus (SE) leads to neurodegeneration, abnormal reorganization of the brain circuitry and a significant loss of functional inhibition. All of these changes likely contribute to the development of chronic epilepsy, characterized by spontaneous recurrent motor seizures (SRMS) and learning and memory deficits. The purpose of this review is to discuss the current state of knowledge pertaining to neuroprotection in epileptic conditions, and to highlight the efficacy of distinct neuroprotective strategies for preventing or treating chronic TLE. Although the administration of certain conventional and new generation anti-epileptic drugs is effective for primary neuroprotection such as reduced neurodegeneration after acute seizures or the SE, their competence for preventing the development of chronic epilepsy after an IPI is either unknown or not promising. On the other hand, alternative strategies such as the ketogenic diet therapy, administration of distinct neurotrophic factors, hormones or antioxidants seem useful for preventing and treating chronic TLE. However, long-term studies on the efficacy of these approaches introduced at different time-points after the SE or an IPI are lacking. Additionally, grafting of fetal hippocampal cells at early time-points after an IPI holds considerable promise for preventing TLE, though issues regarding availability of donor cells, ethical concerns, timing of grafting after SE, and durability of graft-mediated seizure suppression need to be resolved for further advances with this approach. Overall, from the studies performed so far, there is consensus that neuroprotective strategies need to be employed as quickly as possible after the onset of the SE or an IPI for considerable beneficial effects. Nevertheless, ideal strategies that are capable of facilitating repair and functional recovery of the brain after an IPI and preventing the evolution of IPI into chronic epilepsy are still hard to pin down. |
| Colaborador(es) u otros Autores: | Bharathi Hattiangady and Ashok K. Shetty |
| Fecha de publicación : | 2016 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1016/j.pneurobio.2007.10.010. |
| Fuente: | Prog Neurobiol 84(4):363 - 404 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2729 |
| Idioma: | spa |
| Aparece en las colecciones: | Artículos |
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