Por favor, use este identificador para citar o enlazar este ítem:
http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2711| Título : | Prenatal protein malnutrition affects the density of GABAergic interneurons during hippocampus development in rats |
| Creador: | Gonzalez Maciel, Angelica |
| Nivel de acceso: | Open access |
| Palabras clave : | Desnutrición Proteica - patología Neuronas GABAérgicas - patología Neuronas GABAérgicas - citología Hipocampo - anatomía & histología Hipocampo - embriología Hipocampo - patología Giro Dentado - anatomía & histología Giro Dentado - patología Giro Dentado - embriología Protein Malnutrition - pathology GABAergic Neurons - pathology GABAergic Neurons - cytology Hippocampus - anatomy & histology Hippocampus - embryology Hippocampus - patology Dentate Gyrus - anatomy & histology Dentate Gyrus - pathology Dentate Gyrus - embryology Cornu Ammonis Fascia Dentata Hipocampo desnutrición prenatal de proteínas Neuronas GABAérgicas Cornus ammonis Fascia dentata Hippocampus Prenatal protein malnutrition GABAergic neurons |
| Descripción : | Background: Prenatal protein malnutrition disrupts the pattern of maturation and development of the hippocampus and its neuroanatomy and increases inhibition of the granular cell layer of the fascia dentata. If local gamma-aminobutyric acid interneurons are partly responsible for inhibition of the hippocampus, it is reasonable to assume that there may be an increase in the gamma-aminobutyric acid cell population of prenatal protein malnutrition rats. Objective: This experimental study was conducted to ascertain the effects of prenatal protein malnutrition on the density of GABAergic interneurons at the cornus ammonis and fascia dentata in rats. Methods: Animals were investigated under two nutritional conditions: (i) prenatal protein malnutrition group fed 6% protein, and (ii) well-nourished control group fed 25% protein. Using an antibody for gamma-aminobutyric acid, immunoreactive cells (GABAergic) were assessed in the rostral-caudal direction of the dorsal hippocampus at four levels. Results: (i) In 30-day-old rats with prenatal malnutrition, the fascia dentata had an average of 27% more GABAergic cells than the control group; this higher amount was not detectable at 90 days, (ii) There was a significant 18% increase in GABAergic neurons at level 1 of the cornus ammon/s at 90 days of age. Conclusions: There was an increase in the population of interneurons in the fascia dentata and cornus ammonis in prenatal protein malnutrition rats. We conclude that prenatal hypoprotein malnutrition produces changes at 30 days in the fascia dentata. Results suggest that prenatal malnutrition also produces a delay in the programmed chronology of gamma-aminobutyric acid interneurons. Finally, in cornus ammonis, at 90 days of age, prenatal protein malnutrition showed an increase only at level 1; this effect may be evidenced in the long term, despite postnatal rehabilitation. |
| Colaborador(es) u otros Autores: | Romero-Velázquez Rosa María Reynoso-Robles Rafael Uribe-Escamilla Rebeca Vargas-Sánchez Javier De La Garza-Montaño Paloma Alfaro-Rodríguez Alfonso |
| Fecha de publicación : | 2015 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Fuente: | Revista de Investigación Clínica 67(5):296 - 303 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2711 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.