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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2700| Título : | Pontine and cerebellar norepinephrine content in adult rats recovering from focal cortical injury |
| Creador: | Gonzalez Pina, Rigoberto |
| Nivel de acceso: | Open access |
| Palabras clave : | Cerebelo - metabolismo - Ratas Cerebelo - fisiopatología - Ratas Lateralidad Funcional - fisiología - Ratas Técnicas In Vitro - Ratas Locomoción - fisiología - Ratas Corteza Motora - lesiones - Ratas Corteza Motora - fisiopatología - Ratas Norepinefrina - metabolismo - Ratas Puente - metabolismo - Ratas Puente - fisiopatología - Ratas Ratas Wistar Cerebellum - metabolism - Rats Cerebellum - physiopathology - Rats Functional Laterality - physiology - Rats In Vitro Techniques - Rats Locomotion - physiology - Rats Motor Cortex - injuries - Rats Motor Cortex - physiopathology - Rats Norepinephrine - metabolism - Rats Pons - metabolism- Rats Pons - physiopathology - Rats Rats, Wistar Norepinefrina lesión cerebral cerebelo protuberancia diasquisis Norepinephrine Brain injury Pons Cerebellum Diaschisis |
| Descripción : | Norepinephrine (NE) plays an important role in motor recovery after brain damage. Most studies concerning NE activity have been performed in the cerebellum, while the role of the pons, the site where the norepinephrinergic locus coeruleus is located, has not yet been elucidated. For this work, we studied the changes in cerebellar and pontine NE content in sham-operated (n = 17), motor cortex injured (n = 6) and recovered rats (n = 12). Motor effects were assessed by means of footprint analysis and sensorimotor evaluation. It was found that after cortical brain damage, the stride length decreases while the stride angle increases after 6 h post-surgery, while the sensorimotor evaluation showed an increase in the motor deficit. Recovery was observed after 24 h. NE content increased in the pons after 6 h and returned to normal levels in recovered rats, with no significant changes observed in the cerebellum. Based on the functional remote inhibition, it is possible that NE exerts an autoinhibitory effect in the pons after motor cortical ablation. On the other hand, the absence of an effect in the cerebellum suggests that cerebellar NE activity related to damage and/or recovery is limited to discrete areas of the structure. © 2006 Springer Science+Business Media, LLC. |
| Colaborador(es) u otros Autores: | Bueno-Nava A Montes S Alfaro-Rodriguez A Gonzalez-Maciel A Reynoso-Robles R Ayala-Guerrero F |
| Fecha de publicación : | 2006 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1007/s11064-006-9196-6 |
| Fuente: | Neurochemical Research 31(12):1443 - 1449 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2700 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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