Polysomnographic features in infants with early diagnosis of congenital hypothyroidism

Terán Pérez G

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Título :	Polysomnographic features in infants with early diagnosis of congenital hypothyroidism
Creador:	Terán Pérez G
Nivel de acceso:	Open access
Palabras clave :	Encéfalo - crecimiento & desarrollo - recién nacido Hipotiroidismo Congénito - complicaciones - recién nacido Hipotiroidismo Congénito - diagnóstico - recién nacido Hipotiroidismo Congénito - quimioterapia - recién nacido Hipotiroidismo Congénito - fisiopatologia - recién nacido Tamizaje Masivo Polisomnografía - métodos - recién nacido Sueño - fisiologia - recién nacido Apnea del Sueño Central - etiologia - recién nacido Apnea del Sueño Central - fisiopatologia - recién nacido Hormonas Tiroideas - uso terapéutico - recién nacido Brain - growth & development - Infant, Newborn Congenital Hypothyroidism - complications - Infant, Newborn Congenital Hypothyroidism - diagnosis - Infant, Newborn Congenital Hypothyroidism - drug therapy - Infant, Newborn Congenital Hypothyroidism - physiopathology - Infant, Newborn Mass Screening Polysomnography - methods - Infant, Newborn Sleep - physiology - Infant, Newborn Sleep Apnea, Central - etiology - Infant, Newborn Sleep Apnea, Central -physiopathology - Infant, Newborn Thyroid Hormones - therapeutic use - Infant, Newborn Hipotiroidismo congénito, dormir, Apnea del sueño Congenital hypothyroidism; Sleep; Sleep apnea
Descripción :	Thyroid hormones play a major role in the maturation process of the brain. Currently, congenital hypothyroidism is detected by mass screening. The impact of this early hormonal deficiency on the organization of the sleep pattern is not known. In this study, the polysomnographic features in children diagnosed with congenital hypothyroidism were analyzed. Children were detected by mass population screening and the hormonal replacement therapy starts immediately. Children's age ranged between 1.5 and 18 months of age. The duration of hormonal treatment before sleep recordings varied between 8 days and 17 months. Children were polysomnographically recorded in the morning, for at least 2h, obtaining more than one sleep cycle. Results showed a high prevalence of females (5/1) in the group studied. A high proportion of infants (43%) displayed central apnea in different degrees (mild, moderate and severe) as well as hypopnea (83%), mainly in subjects around 4 and 8 months of age. The proportion of infants displaying central apnea decreases as age increases. In addition, indeterminate (light) sleep increase and quiet (slow wave) sleep decrease significantly regardless of age and treatment. The percentage of REM sleep correlated positively with the age of the child at the beginning of the treatment, and negatively with their age at the time of the study. These data indicate that congenital hypothyroidism facilitates the presence of central sleep apnea. The decrease of these respiratory alterations correlates with the increase of the hormonal replacement therapy. It seems that sleep respiratory alterations in congenital hypothyroidism are linked to brain maturation processes in which thyroid hormones play a major role
Colaborador(es) u otros Autores:	Arana-Lechuga Y González-Robles RO Mandujano M Santana-Miranda R Esqueda-Leon E Calzada R Ruiz ML Altamirano N Sánchez C Velázquez-Moctezuma J.
Fecha de publicación :	2010
Tipo de publicación:	Artículo
Formato:	pdf
Identificador del Recurso :	10.1016/j.braindev.2009.07.005
Fuente:	Brain Dev 32(4):332-337
URI :	http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2699
Idioma:	eng
Aparece en las colecciones:	Artículos

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