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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2693| Título : | Plasticity Region Genes jhp0940, jhp0945, jhp0947, and jhp0949 of Helicobacter pylori in Isolates from Mexican Children |
| Creador: | Romo González, Carolina |
| Nivel de acceso: | Open access |
| Palabras clave : | Adolescente Proteínas Bacterianas - genética niño Preescolar Úlcera Duodenal - epidemiología Úlcera Duodenal - microbología Femenino Gastritis - epidemiología Gastritis - microbiología Infecciones por Helicobacter - epidemiología Infecciones por Helicobacter -microbiología Helicobacter pylori - genética Helicobacter pylori - patogenicidad Humanos Masculino México - epidemiología FN-kappa B - metabolismo Úlcera Péptica - epidemiología Úlcera Péptica - microbiología Prevalencia Proteínas Serina-Treonina Quinasas - genética Neoplasias Gástricas - microbiología Virulencia Adolescent Bacterial Proteins - genetics Child Child, Preschool Duodenal Ulcer - epidemiology Duodenal Ulcer - microbiology Female Gastritis - epidemiology Gastritis - microbiology Helicobacter Infections - epidemiology Helicobacter Infections - microbiology Helicobacter pylori - genetics Helicobacter pylori - pathogenicity Humans Male Mexico - epidemiology NF-kappa B - metabolism Peptic Ulcer - epidemiology Peptic Ulcer - microbiology Prevalence Protein-Serine-Threonine Kinases - genetics Stomach Neoplasms - microbiology Virulence Helicobacter pylori niño genes Región de la plasticidad Helicobacter pylori children genes plasticity region |
| Descripción : | Background: The genes jhp0940, jhp0945, jhp0947, and jhp0949 belong to the plasticity region of the Helicobacter pylori genome. Due to their prevalence in isolates from patients with gastritis, duodenal ulcer, and gastric cancer, they have been proposed as markers of gastroduodenal diseases. These genes are associated with pro-inflammatory cytokine induction through the NF-κB activation pathway. Nevertheless, the status of these genes is unknown in H. pylori isolates from children. The aim of the present work was to determine the frequency of the jhp0940-jhp0945-jhp0947-jhp0949 genes in H. pylori isolates from children. Materials and Methods: We identified the jhp0940, jhp0945, jhp0947, and jhp0949 genes and the relationship of each with the virulence factors cagA, cagPAI, and dupA by PCR in 49 isolates of H. pylori from children. The results were corroborated using dot blots. In addition, we compared the prevalence of these genes with the prevalence in adults. Results: The prevalence of jhp0940 (53.1%), jhp0945 (44.9%), jhp0947 (77.6%), and jhp0949 (83.7%) was determined in the isolates from children, as was the prevalence of the virulence genes cagA (63.3%), cagPAI (71.4%), and dupA (37.5%). No association was found between the four genes of the plasticity region and the virulence genes. The presence of the intact locus integrated by jhp0940-jhp0945-jhp0947-jhp0949 was very common among the isolates from children. Conclusion: The genes jhp0940, jhp0947, and jhp0949 were present in more than 50% of the H. pylori isolates, and the joint presence of jhp0940-jhp0945-jhp0947-jhp0949 was very frequent. The frequency of these genes in isolates from children could contribute to the virulence of H. pylori and the evolution of the infection. © 2015 John Wiley & Sons Ltd. |
| Colaborador(es) u otros Autores: | Alejandra Consuelo-Sánchez Margarita Camorlinga-Ponce Norma Velázquez-Guadarrama Magdalena García-Zúñiga Juan Burgueño-Ferreira And Rafael Coria-Jiménez |
| Fecha de publicación : | 2015 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1111/hel.12194 |
| Fuente: | Helicobacter 20(3):231 - 237 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2693 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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