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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2679| Título : | Pediatric Respiratory and Systemic Effects of Chronic Air Pollution Exposure: Nose, Lung, Heart, and Brain Pathology |
| Creador: | Calderón Garcidueñas, Lilian |
| Nivel de acceso: | Open access |
| Palabras clave : | Contaminantes del Aire - efectos adversos Enfermedad de Alzheimer - etiología Enfermedad de Alzheimer - metabolismo Enfermedad de Alzheimer - patología Encéfalo - efectos de drogas Encéfalo - Metabolismo Encéfalo - Patología Monitoreo ambiental Corazón - efectos de drogas Exposición por Inhalación - efectos adversos Pulmón - efectos de drogas Pulmón - Patología México Miocardio - patología Nariz - efectos de drogas Nariz - patología Material Particulado - efectos adversos Salud urbana Air Pollutants - adverse effects Alzheimer Disease - etiology Alzheimer Disease - metabolism Alzheimer Disease - pathology Brain - drug effects Brain - metabolism Brain - pathology Environmental Monitoring Heart - drug effects Inhalation Exposure - adverse effects Lung - drug effects Lung - pathology Mexico Myocardium - pathology Nose - drug effects Nose/pathology Particulate Matter - adverse effects Urban Health Children particulate matter systemic inflammation beta-amyloid nasal epithelial barrier air pollution Alzheimer disease early risk factors. |
| Descripción : | Exposures to particulate matter and gaseous air pollutants have been associated with respiratory tract inflammation, disruption of the nasal respiratory and olfactory barriers, systemic inflammation, production of mediators of inflammation capable of reaching the brain and systemic circulation of particulate matter. Mexico City (MC) residents are exposed to significant amounts of ozone, particulate matter and associated lipopolysaccharides. MC dogs exhibit brain inflammation and an acceleration of Alzheimer's-like pathology, suggesting that the brain is adversely affected by air pollutants. MC children, adolescents and adults have a significant upregulation of cyclooxygenase-2 (COX2) and interleukin-1β (IL-1β) in olfactory bulb and frontal cortex, as well as neuronal and astrocytic accumulation of the 42 amino acid form of β-amyloid peptide (Aβ42), including diffuse amyloid plaques in frontal cortex. The pathogenesis of Alzheimer's disease (AD) is characterized by brain inflammation and the accumulation of Aβ42, which precede the appearance of neuritic plaques and neurofibrillary tangles, the pathological hallmarks of AD. Our findings of nasal barrier disruption, systemic inflammation, and the upregulation of COX2 and IL-1β expression and Aβ42 accumulation in brain suggests that sustained exposures to significant concentrations of air pollutants such as particulate matter could be a risk factor for AD and other neurodegenerative diseases. © 2007, SAGE Publications. All rights reserved. |
| Colaborador(es) u otros Autores: | Maricela Franco-Lira Ricardo Torres-Jardón Carlos Henríquez-Roldan Gerardo Barragán Mejía Gildardo Valencia Salazar Angelica González Maciel Rafael Reynoso-Robles Rafael Villarreal Calderón William Reed |
| Fecha de publicación : | 2007 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1080/01926230601059985 |
| Fuente: | Toxicologic Pathology 35(1):154 - 162 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2679 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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