Oxidative stress induced by morphine in brain of rats fed with a protein deficient diet

Calderón Guzmán, David

Por favor, use este identificador para citar o enlazar este ítem: http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2667

Título :	Oxidative stress induced by morphine in brain of rats fed with a protein deficient diet
Creador:	Calderón Guzmán, David
Nivel de acceso:	Open access
Palabras clave :	Analgésicos Opioides - efectos adversos - ratas Antioxidantes - metabolismo - ratas Biomarcadores - metabolismo - ratas Encéfalo -efectos de drogas - ratas Encéfalo -enzimologia - ratas Encéfalo - metabolismo - ratas Relación Dosis-Respuesta a Droga - ratas Morfina - efectos adversos - ratas Estrés Oxidativo - efectos adversos - ratas Deficiencia de Proteína - metabolismo - ratas Ratas Wistar Analgesics, Opioid - adverse effects - rats Antioxidants - metabolism - rats Biomarkers - metabolism - rats Brain - drug effects - rats Brain - enzymology - rats Brain - metabolism - rats Dose-Response Relationship, Drug - rats Morphine - adverse effects - rats Oxidative Stress - drug effects - rats Protein Deficiency - metabolism - rats Rats, Wistar Aminas biógenas, cerebro, glutatión, malnutrición, morfina, estrés oxidativo Biogenic amines, brain, glutathione, malnutrition, morphine, oxidative stress
Descripción :	The objective of the study is to determine the damage by oxidative stress induced by morphine in brain of rats fed with a protein-deficient diet. Twenty-eight malnourished male Wistar rats, 30 days old, were used in the study. The animals were divided into four groups of 7 rats per group. Group I received NaCl and the groups II; III and IV intraperitoneally received 3, 6 and 12 mg/kg of morphine sulphate, respectively, in a single dose. Animals were sacrificed and the levels of glutathione (GSH), dopamine, tryptophan and 5-hydroxyindole-3-acetic acid (5-HIAA) as well as, Na+/K+ ATPase and total ATPase activity in the brain were measured. Tryptophan levels and Na+/K+ ATPase activity showed non-significant changes in the experimental group. Levels of 5-HIAA decreased significantly (p =.03) in animals that received 12 mg/kg of morphine and in animals that received 3 mg/kg, levels of GSH and dopamine were found to have a significant decrease (p <.05), but a significant increase in the group that received 12 mg/kg of morphine (p <.05). Total ATPase activity increased significantly in the groups that received 3 mg/kg (p =.015) and 6 mg/kg (p =.0001) of morphine. The results show that malnutrition induces changes in cellular regulation and biochemical responses to oxidative stress caused by morphine sulphate.
Colaborador(es) u otros Autores:	Osnaya-Brizuela N García-Alvarez R Hernández-García E Juárez-Olguín H
Fecha de publicación :	2009
Tipo de publicación:	Artículo
Formato:	pdf
Identificador del Recurso :	10.1177/0960327109102798
Fuente:	Human and Experimental Toxicology 28(9):577 - 582
URI :	http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2667
Idioma:	eng
Aparece en las colecciones:	Artículos

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