Por favor, use este identificador para citar o enlazar este ítem:
http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2660| Título : | Oregano (Lippia spp.) kills Giardia intestinalis trophozoites in vitro: Antigiardiasic activity and ultrastructural damage |
| Creador: | Ponce Macotela, Martha |
| Nivel de acceso: | Open access |
| Palabras clave : | Antiprotozoarios - farmacología Núcleo Celular - ultraestructura Supervivencia Celular Giardia lamblia - efectos de drogas Giardia lamblia - ultraestructura humanos Microscopía Electrónica de Transmisión Origanum - química Extractos Vegetales - farmacología Coloración y Etiquetado Sales de Tetrazolio - metabolismo Tiazoles - metabolismo Trofozoítos - efectos de drogas Antiprotozoal Agents - pharmacology Cell Nucleus - ultrastructure Cell Survival Giardia lamblia - drug effects Giardia lamblia - ultrastructure Microscopy, Electron, Transmission Origanum - chemistry Plant Extracts - pharmacology Staining and Labeling Tetrazolium Salts - metabolism Thiazoles - metabolism Trophozoites - drug effects |
| Descripción : | In the world, giardiosis is still a very important parasitic disease; only in Asia, Africa and America, there are more than 200 million of infected people in a year. The usual treatments are drugs that produce undesirable secondary effects, perhaps favouring the resistant strain selection. One alternative is to research compounds from plants used as antidiarrhoeic or antiparasitic in the traditional medicine. In a previous work, we found that Lippia beriandieri (Oregano) revealed to be more potent than tinidazole, a common antigiardiasic drug. In this current work, we tested the cell viability by re-culture and reduction of MTT-tetrazolium salts to MTT-formazan, and we showed the effect of oregano ethanolic extracts against Giardia intestinalis (synonyms: Giardia duodenalis, Giardia lamblia) trophozoites at concentrations ranging form 58 to 588 microg. We demonstrated the ultrastructural injury produced by oregano extracts in this parasite. Trophozoites lost their size and shape and showed damage in nucleus structure, perhaps by breaking the pattern of nucleoskeleton proteins |
| Colaborador(es) u otros Autores: | Rufino-Gonzalez Y Gonzalez-Maciel A Reynoso-Robles R Martinez-Gordillo Mn. |
| Fecha de publicación : | 2006 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1007/s00436-005-0082-y |
| Fuente: | Parasitology Research 98(6):557 - 560 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2660 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.