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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2654| Título : | Nordihydroguaiaretic acid is a potent in vitro scavenger of peroxynitrite, singlet oxygen, chlorous acid and prevents in vivo ozone-induced tyrosine nitrationin lungs |
| Creador: | Floriano Sánchez, Esaú |
| Nivel de acceso: | Open access |
| Palabras clave : | Antioxidantes - Química Antioxidantes - farmacología Relación Dosis-Respuesta a Droga Depuradores de Radicales Libres - Química Depuradores de Radicales Libres - farmacología Radical Hidroxilo - metabolismo Ácido Hipocloroso - metabolismo Inmunohistoquímica Pulmón - efectos de drogas Pulmón - metabolismo masculino Masoprocol - Química Masoprocol - farmacología Ozono - farmacología Ácido Peroxinitroso - metabolismo Ratas Wistar Especies de Oxígeno Reactivo - metabolismo Oxígeno Singlete - metabolismo Superóxidos - metabolismo Tirosina - metabolismo Antioxidants - chemistry Antioxidants - pharmacology Dose-Response Relationship, Drug Free Radical Scavengers - chemistry Free Radical Scavengers - pharmacology Hydroxyl Radical - metabolism Hypochlorous Acid - metabolism Immunohistochemistry Lung - drug effects Lung - metabolism Masoprocol - chemistry Masoprocol - pharmacology Ozone - pharmacology Peroxynitrous Acid - metabolism Rats, Wistar Reactive Oxygen Species - metabolism Singlet Oxygen - metabolism Superoxides - metabolism Tyrosine - metabolism ácido Nordihydroguaiaretic carroñero peroxinitrito el oxígeno singlete radical hidroxilo anión superóxido Nordihydroguaiaretic acid scavenger peroxynitrite singlet oxygen hydroxyl radical superoxide anion |
| Descripción : | The antioxidant nordihydroguaiaretic acid (NDGA) has recently become well known as a putative anticancer drug. In this paper, it was evaluated the in vitro peroxynitrite (ONOO(-)), singlet oxygen ((1)O(2)), hydroxyl radical (OH(v)), hydrogen peroxide (H(2)O(2)), superoxide anion and hypochlorous acid (HOCl) scavenging capacity of NDGA. It was found that NDGA scavenges: (a) ONOO(-) (IC(50) = 4 +/- 0.94 microM) as efficiently as uric acid; (b) (1)O(2) (IC(50) = 151 +/- 20 microM) more efficiently than dimethyl thiourea, lipoic acid, N-acetyl-cysteine and glutathione; (c) OH(v) (IC(50) = 0.15 +/- 0.02 microM) more efficiently than dimethyl thiourea, uric acid, trolox, dimethyl sulfoxide and mannitol, (d) (IC(50) = 15 +/- 1 microM) more efficiently than N-acetyl-cysteine, glutathione, tempol and deferoxamine and (e) HOCl (IC(50) = 622 +/- 42 microM) as efficiently as lipoic acid and N-acetyl-cysteine. NDGA was unable to scavenge H(2)O(2). In an in vivo study in rats, NDGA was able to prevent ozone-induced tyrosine nitration in lungs. It is concluded that NDGA is a potent in vitro scavenger of ONOO(-), (1)O(2), OH(v), and HOCl and is able to prevent lung tyrosine nitration in vivo. |
| Colaborador(es) u otros Autores: | Villanueva C Medina-Campos On Rocha D Cardenas-Rodriguez N Pedraza-Chaverri J |
| Fecha de publicación : | 2006 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1080/10715760500419365 |
| Fuente: | Free Radical Research 40(5):523-533 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2654 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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