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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2635| Título : | Neonatal exposure to monosodium glutamate induces morphological alterations in suprachiasmatic nucleus of adult rat |
| Creador: | Rojas Castañeda, Julio César |
| Nivel de acceso: | Open access |
| Palabras clave : | Animales Recuento de células Mujer Proteína Ácida Fibrilar de la Glía - Metabolismo masculino Neuronas - efectos de drogas Neuronas - metabolismo Ratas Wistar Glutamato de Sodio - farmacología Núcleo Supraquiasmático - efectos de drogas Núcleo supraquiasmático - crecimiento y desarrollo Péptido Intestinal Vasoactivo - metabolismo Vasopresinas - Metabolismo Animals Cell Count Female Glial Fibrillary Acidic Protein - metabolism Male Neurons - drug effects Neurons - metabolism Rats, Wistar Sodium Glutamate - pharmacology Suprachiasmatic Nucleus - drug effects Suprachiasmatic Nucleus - growth & development Vasoactive Intestinal Peptide/metabolism Vasopressins/metabolism proteína ácida fibrilosa glial; actividad locomotriz; glutamato monosódico; núcleo supraquiasmático; polipéptido intestinal vasoactivo; vasopresina glial fibrillary acidic protein; locomotor activity; monosodium glutamate; suprachiasmatic nucleus; vasoactive intestinal polypeptide; vasopressin |
| Descripción : | Neonatal exposure to monosodium glutamate (MSG) induces circadian disorders in several physiological and behavioural processes regulated by the suprachiasmatic nucleus (SCN). The objective of this study was to evaluate the effects of neonatal exposure to MSG on locomotor activity, and on morphology, cellular density and expression of proteins, as evaluated by optical density (OD), of vasopressin (VP)-, vasoactive intestinal polypeptide (VIP)- and glial fibrillary acidic protein (GFAP)-immunoreactive cells in the SCN. Male Wistar rats were used: the MSG group was subcutaneously treated from 3 to 10 days of age with 3.5 mg/g/day. Locomotor activity was evaluated at 90 days of age using 'open-field' test, and the brains were processed for immunohistochemical studies. MSG exposure induced a significant decrease in locomotor activity. VP- and VIP-immunoreactive neuronal densities showed a significant decrease, while the somatic OD showed an increase. Major axes and somatic area were significantly increased in VIP neurons. The cellular and optical densities of GFAP-immunoreactive sections of SCN were significantly increased. These results demonstrated that newborn exposure to MSG induced morphological alterations in SCN cells, an alteration that could be the basis for behavioural disorders observed in the animals. International Journal of Experimental Pathology © 2016 International Journal of Experimental Pathology. |
| Colaborador(es) u otros Autores: | Vigueras-Villaseñor Rosa María Chavez-Saldaña Margarita Gutierez-Perez Oscar Rojas Carolina Arteaga-Silva Marcela |
| Fecha de publicación : | 2016 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1111/iep.12157 |
| Fuente: | International Journal of Experimental Pathology 97(1):18 - 26 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2635 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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