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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2629| Título : | Mycobacterial disease in patients with chronic granulomatous disease: A retrospective analysis of 71 cases |
| Creador: | Francesca Conti |
| Nivel de acceso: | Open access |
| Palabras clave : | Enfermedad Granulomatosa Crónica - genética Enfermedad Granulomatosa Crónica - inmunología Vacuna BCG - clasificación Vacuna BCG - efectos adversos Tuberculosis - diagnóstico Tuberculosis - epidemiología Tuberculosis - genética Tuberculosis - prevención & control Tuberculosis - microbiología Mycobacterium tuberculosis - inmunología Mycobacterium tuberculosis - aislamiento & purificación Radiografía Torácica Fenotipo Fagocitosis - genética Granulomatous Disease, Chronic - genetics Granulomatous Disease, Chronic - immunity BCG Vaccine - classification BCG Vaccine - adverse effects Tuberculosis - diagnosis Tuberculosis - epidemiology Tuberculosis - genetics Tuberculosis - prevention & control Tuberculosis - microbiology Mycobacterium tuberculosis - immunology Mycobacterium tuberculosis - isolation & purification Radiography, Thoracic Phenotype Phagocytosis - genetics Micobacterias BCG Enfermedad granulomatosa crónica tuberculosis Inmunodeficiencia primaria Mycobacteria BCG chronic granulomatous disease tuberculosis primary immunodeficiency |
| Descripción : | Background Chronic granulomatous disease (CGD) is a rare primary immunodeficiency caused by inborn errors of the phagocyte nicotinamide adenine dinucleotide phosphate oxidase complex. From the first year of life onward, most affected patients display multiple, severe, and recurrent infections caused by bacteria and fungi. Mycobacterial infections have also been reported in some patients. Objective Our objective was to assess the effect of mycobacterial disease in patients with CGD. Methods We analyzed retrospectively the clinical features of mycobacterial disease in 71 patients with CGD. Tuberculosis and BCG disease were diagnosed on the basis of microbiological, pathological, and/or clinical criteria. Results Thirty-one (44%) patients had tuberculosis, and 53 (75%) presented with adverse effects of BCG vaccination; 13 (18%) had both tuberculosis and BCG infections. None of these patients displayed clinical disease caused by environmental mycobacteria, Mycobacterium leprae, or Mycobacterium ulcerans. Most patients (76%) also had other pyogenic and fungal infections, but 24% presented solely with mycobacterial disease. Most patients presented a single localized episode of mycobacterial disease (37%), but recurrence (18%), disseminated disease (27%), and even death (18%) were also observed. One common feature in these patients was an early age at presentation for BCG disease. Mycobacterial disease was the first clinical manifestation of CGD in 60% of these patients. Conclusion Mycobacterial disease is relatively common in patients with CGD living in countries in which tuberculosis is endemic, BCG vaccine is mandatory, or both. Adverse reactions to BCG and severe forms of tuberculosis should lead to a suspicion of CGD. BCG vaccine is contraindicated in patients with CGD. © 2016 American Academy of Allergy, Asthma & Immunology |
| Colaborador(es) u otros Autores: | Lugo-Reyes Saul Oswaldo Blancas Galicia Lizbeth He Jiaxin Aksu Güside Borges De Oliveira Edgar Deswarte C Hubeau M Karaca N De Suremain M Guérin A Baba La Prando C Guerrero Gg Emiroglu M Öz Fn Yamazaki Nakashimada Ma Gonzalez Serrano E Espinosa S Barlan I Pérez N Regairaz L Guidos Morales He Bezrodnik L Di Giovanni D Dbaibo G Ailal F Galicchio M Oleastro M Chemli J Danielian S Perez L Ortega Mc Soto Lavin S Hertecant J Anal O Kechout N Al-Idrissi E Elghazali G Bondarenko A Chernyshova L Ciznar P Herbigneaux Rm Diabate A Ndaga S Konte B Czarna A Migaud M Pedraza-Sánchez S Zaidi Mb Vogt G Blanche S Benmustapha I Mansouri D Abel L Boisson-Dupuis S Mahlaoui N Bousfiha Aa Picard C Barbouche R Al-Muhsen S Espinosa-Rosales Fj Kütükçüler N Condino-Neto A Casanova JL Bustamante J. |
| Fecha de publicación : | 2016 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1016/j.jaci.2015.11.041 |
| Fuente: | Journal of Allergy and Clinical Immunology 138(1):241-248 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2629 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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