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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2620| Título : | Acute infection of Toxoplasma gondii and cytomegalovirus reactivation in a pediatric patient receiving liver transplant |
| Creador: | Galvan Ramirez, M.L. |
| Nivel de acceso: | Open access |
| Palabras clave : | Antivirales - uso terapéutico - niño Citomegalovirus - aislamiento y purificación - niño Infecciones por Citomegalovirus - quimioterapia - niño Infecciones por citomegalovirus - parasitología - niño Infecciones por citomegalovirus - virología - niño Ganciclovir - uso terapéutico - niño trasplante de hígado - métodos - niño Complicaciones Posoperatorias - parasitología - niño Complicaciones Posoperatorias - virología - niño Toxoplasma - aislamiento y purificación - niño Toxoplasmosis - parasitología - niño Toxoplasmosis - virología - niño Retina -lesiones - niño Antiviral Agents - therapeutic use - child Cytomegalovirus - isolation & purification - child Cytomegalovirus Infections - drug therapy - child Cytomegalovirus Infections -parasitology - child Cytomegalovirus Infections - virology - child Ganciclovir - therapeutic use - child Liver Transplantation - methods - child Postoperative Complications - parasitology - child Postoperative Complications virology .- child Toxoplasma - isolation & purification - child Toxoplasmosis - parasitology - child Toxoplasmosis - virology - child Retina - injuries - child Citomegalovirus trasplante de hígado Toxoplasma gondii Cytomegalovirus liver transplantation Toxoplasma gondii |
| Descripción : | A 7-year-old Mexican boy with end-stage cirrhosis underwent liver transplantation and was maintained with cyclosporine and prednisolone. No specific data about Toxoplasma gondii or cytomegalovirus (CMV) infections in the cadaver donor were available. The recipient was seronegative for Toxoplasma, but CMV-IgG positive before transplantation. Ganciclovir was administered for prophylaxis during 3 months, but 5 months later he presented with icterus and increased transaminases. Acute transplant rejection was ruled out by biopsy. A seroconversion for T. gondii IgM and IgG and a small increase in CMV-IgM antibodies were observed, although the CMV-polymerase chain reaction (PCR) was negative. Ganciclovir was re-started, and the patient improved, but 6 months later he relapsed, and chorioretinitis lesions compatible both with T. gondii and CMV infections appeared. Pyrimethamine, sulfadiazine, folinic acid, and ganciclovir were administered. The boy showed favorable clinical improvement and remained stable for 12 months. Then, new retinal CMV lesions appeared in both eyes and the PCR for CMV became positive; therefore, the patient received a new regimen of ganciclovir, and clinically improved. From these data we concluded that the child presented a reactivation of CMV and a primary infection with T. gondii after transplantion. Copyright © Blackwell Munksgaard 2006. |
| Colaborador(es) u otros Autores: | Castillo-De-Leon Y. Espinoza-Oliva M. Bojorques-Ramos M.C. Rodríguez-Pérez L.R. Bernal Redondo R. I. Cañedo-Solares I. Espinoza López L. Correa D. |
| Fecha de publicación : | 2006 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1111/j.1399-3062.2006.00140.x |
| Fuente: | Transplant Infectious Disease 8(4):233 - 236 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2620 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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