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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2579| Título : | Local and Circulating Microchimerism Is Associated Local and Circulating Microchimerism Is Associated with Hypersensitivity Pneumonitis |
| Creador: | Bustos, Martha L. |
| Nivel de acceso: | Open access |
| Palabras clave : | Alveolitis Alérgica Extrínseca - genética Alveolitis Alérgica Extrínseca - Inmunología 4.- Líquido del Lavado Bronquioalveolar - citología Proteínas de Ciclo Celular - genética Quimera - Inmunología Quimerismo Mujer Pulmón - citología Mediana Edad Fibrosis Pulmonar - genética Alveolitis, Extrinsic Allergic - genetics Alveolitis, Extrinsic Allergic - immunology Bronchoalveolar Lavage Fluid - cytology Cell Cycle Proteins - genetics Chimera - immunology Chimerism Lung - cytology Male Middle Aged Pulmonary Fibrosis - genetics alveolitis alérgica extrínseca neumonitis de la hipersensibilidad microquimerismo allergic extrinsic alveolitis hypersensitivity pneumonitis microchimerism |
| Descripción : | Rationale: Hypersensitivity pneumonitis (HP) is a lymphocytic alveolitis provoked by exposure to a variety of antigens. However, the disease occurs in only a subset of exposed individuals, suggesting that additional factors may be involved. Microchimerism has been implicated in the pathogenesis of autoimmune diseases, especially in those showing increased incidence after childbearing age. Objectives: To evaluate the presence of circulating and local microchimeric cells in female patients with HP. Methods: Male microchimerism was examined in 103 patients with HP, 30 with idiopathic pulmonary fibrosis (IPF), and 43 healthy women. All of them had given birth to at least one son, with no twin siblings, blood transfusions, or transplants. Microchimerism was examined by dot blot hybridization (peripheral blood), and by fluorescence in situ hybridization in bronchoalveolar lavage cells and lungs. |
| Colaborador(es) u otros Autores: | Sara Frías Sandra Ramos Andrea Estrada José Luis Arreola Felipe Mendoza Miguel Gaxiola Mauricio Salcedo Annie Pardo Moisés Selman |
| Fecha de publicación : | 2007 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1164/rccm.200608-1129OC |
| Fuente: | Am J Resp Crit Care 176(1):90-95 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2579 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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