Por favor, use este identificador para citar o enlazar este ítem:
http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2578| Título : | Lipid peroxidation inhibition in spinal cord injury: cyclosporin-A vs methylprednisolone |
| Creador: | Diaz Ruiz, A |
| Nivel de acceso: | Open access |
| Palabras clave : | Ciclosporina - farmacología Combinación de Medicamentos Peróxidos Lipídicos - antagonistas e inhibidores Metilprednisolona - farmacología Fármacos Neuroprotectores - farmacología Ratas Traumatismos de la Médula Espinal - metabolismo Traumatismos de la Médula Espinal - fisiopatología Análisis de Supervivencia Cyclosporine - pharmacology Drug Combinations Lipid Peroxides - antagonists & inhibitors Methylprednisolone - pharmacology Neuroprotective Agents - pharmacology Rats Spinal Cord Injuries - metabolism Spinal Cord Injuries - physiopathology Survival Analysis Ciclosporina paraplejia experimental Radicales Libres Respuesta inflamatoria Peroxidación de Lípido Metilprednisolona Neuroprotección Lesión de la médula espinal Supervivencia Cyclosporin- A Experimental paraplegia Free radicals Inflammatory response Lipid peroxidation Methylprednisolone Neuroprotection Spinal cord injury Survival |
| Descripción : | To compare the effectiveness of cyclosporin-A (CsA) with methylprednisolone (MP) or a combination of both upon inhibition of lipid peroxidation(LP) after spinal cord (SC) injury, rats were treated with either CsA, MP, CSA+MP or vehicle starting 1 h after SC contusion at T9 level. LP was assessed 24h after injury by the lipid fluorescent product formation method. The survival rate was also evaluated in other series of rats by the Kaplan-Meier curves. Lipid peroxidation was similarly inhibited in rats treated with CsA, MP, or CSA+MP (p>0.05). Animals receiving MP (alone or combined with CsA) showed the poorest surviving rate. LP was inhibited by CsA to the same extent as by MP but without the lethal effect of the latter |
| Colaborador(es) u otros Autores: | Rios C Duarte I Correa D Guizar Sahagun G Grijalva I Madrazo I Ibarra A |
| Fecha de publicación : | 2000 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Fuente: | Neuroreport 11(8):1765-7 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2578 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.