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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2567| Título : | L. monocytogenes induces overexpression of proinflammatory IL-36 cytokines in a murine model of early pregnancy |
| Creador: | Murrieta Coxca J |
| Nivel de acceso: | Open access |
| Palabras clave : | Células Asesinas Inducidas por Citocinas - inmunología Células Asesinas Inducidas por Citocinas - patología Citocinas - inmunología Útero - inmunología - ratones Embarazo - inmunología Endometrio - inmunología Endometrio - patología Interleucina-6 - inmunología Cytokine-Induced Killer Cells - immunology Cytokine-Induced Killer Cells - pathology Cytokines - immunology Pregnancy - immunology Endometrium - immunology Endometrium - pathology Interleukin-6 - immunology Embarazo, Endometrio, Citocinas, Interleucina-6, L. monocytogenes, IL-36 Citocinas Pregnancy, Endometrium, Cytokines, Interleukin-6, L. monocitógenos, IL-36 cytokines |
| Descripción : | During the pregnancy process the participation of proinflammatory cytokines such as IL-1, TNF-α and IL-6 has been involved mainly during implantation and delivery. IL-36 cytokines (IL-36-α, -β, -γ, Ra (antagonist)) and the receptor IL-36R has been related to inflammatory disorders but so far it is unknown if they participate in the normal pregnancy success. We seek the IL-36 expression profile in uterus of non-pregnant and pregnant mice at different stages of hormonal cycle, implantation, fetal development, labor, as well as postdelivery. We found that IL-36 (α, β and γ) and IL-36R are expressed along the estrous cycle and during pregnancy, and considering IL-36 expression at diestrus as basal, the highest expression of IL-36 (α, β and γ) and IL-36R occurred at the estrus stage and during labor. IL-36 (α, β, γ and Ra) decreased to basal levels at post-labor. We did histological analysis and we found that IL-36 (α, β, γ and Ra) and their receptor are located mainly in the endometrium. Finally, we used an infection model with L. monocytogenes finding that it induced the overexpression of IL-36 (α, β and γ) and IL-36R at the implantation period. IL-36Ra was mainly expressed in the last days of implantation period. Our results give evidence, for the first time, of the differential expression of IL-36 (α, β, γ and Ra) and their histological location in uteri tissues of non-pregnant, healthy pregnant and infected pregnant mice. |
| Colaborador(es) u otros Autores: | Gómez-Chávez Fernando Cancino-Díaz Me Cancino-Díaz Jc Rodriguez-Martinez S |
| Fecha de publicación : | 2016 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1016/j.jri.2016.04.169 |
| Fuente: | Journal of Reproductive Immunology 115():55 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2567 |
| Idioma: | spa |
| Aparece en las colecciones: | Artículos |
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