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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2557| Título : | Is Toxoplasma gondii type related to clinical outcome in human congenital infection? Systematic and critical review |
| Creador: | Rico Torres Claudia, Patricia |
| Nivel de acceso: | Open access |
| Palabras clave : | Adulto Femenino Genotipo Edad Gestacional Humanos Recién nacido Oportunidad Relativa Evaluación del Resultado de la Atención al Paciente Embarazo Resultado del Embarazo Toxoplasma - clasificación Toxoplasma - genética Toxoplasmosis Congénita - epidemiología Toxoplasmosis Congénita - parasitología Toxoplasmosis Congénita - transmisión Adult Female Genotype Gestational Age Humans Infant, Newborn Odds Ratio Patient Outcome Assessment Pregnancy Pregnancy Outcome Toxoplasma - classification Toxoplasma - genetics Toxoplasmosis, Congenital - epidemiology Toxoplasmosis, Congenital - parasitology Toxoplasmosis, Congenital - transmission Toxoplasmosis, Prenatal, Genotipos, embarazo, Toxoplasma gondii Toxoplasmosis, Congenital, Genotype, Pregnancy, Toxoplasma |
| Descripción : | In human congenital toxoplasmosis the effects of parasite burden and pregnancy time at infection on clinical outcome are well known, but there is controversy regarding the role of Toxoplasma gondii type. Through a systematic review of the literature, we aimed to discern if T. gondii type has a role on clinical outcome in human congenital toxoplasmosis. We built up a database of congenital toxoplasmosis from reports of cases, case series and screening-based cohorts, which had information about parasite type, gestation time at maternal infection and/or clinical outcome in the product. Then, we obtained frequencies for loci used to genotype geographical origin of cases and types found. Also, odds ratios were calculated for association between time of maternal infection or parasite type on outcome. Type II parasites were the most common in Europe, Asia and Africa, while in America there were mainly atypical strains. More newborns with clinical problems were born from mothers infected during the first half of gestation than from those acquiring the parasite after week 24, regardless of parasite genotype (92.9 vs. 16.1 %, OR = 67.9, CI95 25.4–181.6). Type I and atypical parasites were associated with clinical problems as opposed to types II and III, regardless of pregnancy period at infection (86.9 vs. 72.9 %, OR = 2.47, CI95 1.1–5.4). A significant and remarkable tendency of type I parasites to be present during early pregnancy was also observed (94.4 vs. 5.6 %, P < 0.009). In addition to parasite burden and period of gestation, T. gondii genotype seems involved in CT clinical outcome. © 2016, Springer-Verlag Berlin Heidelberg. |
| Colaborador(es) u otros Autores: | Vargas-Villavicencio José Antonio Correa Beltran María Dolores |
| Fecha de publicación : | 2016 |
| Tipo de publicación: | Revisión |
| Formato: | |
| Identificador del Recurso : | 10.1007/s10096-016-2656-2 |
| Fuente: | European Journal of Clinical Microbiology and Infectious Diseases 35(7):1079 - 1088 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2557 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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