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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2513| Título : | Immunotoxicity and environment: Immunodysregulation and systemic inflammation in children |
| Creador: | Calderón Garcidueñas, Lilian |
| Nivel de acceso: | Open access |
| Palabras clave : | Contaminantes del Aire - análisis - niño - México Contaminantes del Aire - toxicidad - niño - México Contaminantes del Aire - efectos adversos - niño - México Cohort Studies Exposición a Riesgos Ambientales - efectos adversos - niño - México Exposición a Riesgos Ambientales - prevención & control - niño - México Inflamación - sangre - niño - México Inflamación - inducido químicamente - niño - México Inflamación - inmunologia - niño - México Exposición por Inhalación - efectos adversos - niño - México Exposición por Inhalación - prevención & control - niño - México Material Particulado - niño - México Air Pollutants - analysis - child - Mexico Air Pollutants - toxicity - child - Mexico Air Pollution - adverse effects - child - Mexico Air Pollution - analysis - child - Mexico Cohort Studies Environmental Exposure - adverse effects - child - Mexico Environmental Exposure - prevention & control - child - Mexico Inflammation - blood - child - Mexico Inflammation - chemically induced - child - Mexico Inflammation - immunology - child - Mexico Inhalation Exposure - adverse effects - child - Mexico Inhalation Exposure - prevention & control - child - Mexico Particulate Matter - child - Mexico niños, contaminación del aire, materia particulada, células de asesino naturales, tolerancia de endotoxina, inmunidad, inflamación sistémica children; air pollution; particulate matter; natural killer cells; endotoxin tolerance; immunity; systemic inflammation |
| Descripción : | Environmental pollutants, chemicals, and drugs have an impact on children's immune system development. Mexico City (MC) children exposed to significant concentrations of air pollutants exhibit chronic respiratory inflammation, systemic inflammation, neuroinflammation, and cognitive deficits. We tested the hypothesis that exposure to severe air pollution plays a role in the immune responses of asymptomatic, apparently healthy children. Blood measurements for markers of immune function, inflammatory mediators, and molecules interacting with the lipopolysaccharide recognition complex were obtained from two cohorts of matched children (aged 9.7 ± 1.2 years) from southwest Mexico City (SWMC) (n = 66) and from a control city (n = 93) with criteria pollutant levels below current standards. MC children exhibited significant decreases in the numbers of natural killer cells (p =.003) and increased numbers of mCD14+ monocytes (p <.001) and CD8+ cells (p =.02). Lower concentrations of interferon (p =.009) and granulocyte-macrophage colony-stimulating factor (p <.001), an endotoxin tolerance-like state, systemic inflammation, and an anti-inflammatory response were also present in the highly exposed children. C-reactive protein and the prostaglandin E metabolite levels were positively correlated with twenty-four- and forty-eight-hour cumulative concentrations of PM2.5. Exposure to urban air pollution is associated with immunodysregulation and systemic inflammation in children and is a major health threat. Copyright © 2009 by Society of Toxicologic Pathology. |
| Colaborador(es) u otros Autores: | Macías-Parra M Hoffmann HJ Valencia-Salazar G Henríquez-Roldán C Osnaya N Monte OC Barragán-Mejía G Villarreal-Calderon R Romero L Granada-Macías M Torres-Jardón R Medina-Cortina H Maronpot RR. |
| Fecha de publicación : | 2009 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1177/0192623308329340 |
| Fuente: | Toxicologic Pathology 37(2):161 - 169 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2513 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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