Por favor, use este identificador para citar o enlazar este ítem: http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2513
Título : Immunotoxicity and environment: Immunodysregulation and systemic inflammation in children
Creador: Calderón Garcidueñas, Lilian
Nivel de acceso: Open access
Palabras clave : Contaminantes del Aire - análisis - niño - México
Contaminantes del Aire - toxicidad - niño - México
Contaminantes del Aire - efectos adversos - niño - México
Cohort Studies
Exposición a Riesgos Ambientales - efectos adversos - niño - México
Exposición a Riesgos Ambientales - prevención & control - niño - México
Inflamación - sangre - niño - México
Inflamación - inducido químicamente - niño - México
Inflamación - inmunologia - niño - México
Exposición por Inhalación - efectos adversos - niño - México
Exposición por Inhalación - prevención & control - niño - México
Material Particulado - niño - México
Air Pollutants - analysis - child - Mexico
Air Pollutants - toxicity - child - Mexico
Air Pollution - adverse effects - child - Mexico
Air Pollution - analysis - child - Mexico
Cohort Studies
Environmental Exposure - adverse effects - child - Mexico
Environmental Exposure - prevention & control - child - Mexico
Inflammation - blood - child - Mexico
Inflammation - chemically induced - child - Mexico
Inflammation - immunology - child - Mexico
Inhalation Exposure - adverse effects - child - Mexico
Inhalation Exposure - prevention & control - child - Mexico
Particulate Matter - child - Mexico
niños, contaminación del aire, materia particulada, células de asesino naturales, tolerancia de endotoxina, inmunidad, inflamación sistémica
children; air pollution; particulate matter; natural killer cells; endotoxin tolerance; immunity; systemic inflammation
Descripción : Environmental pollutants, chemicals, and drugs have an impact on children's immune system development. Mexico City (MC) children exposed to significant concentrations of air pollutants exhibit chronic respiratory inflammation, systemic inflammation, neuroinflammation, and cognitive deficits. We tested the hypothesis that exposure to severe air pollution plays a role in the immune responses of asymptomatic, apparently healthy children. Blood measurements for markers of immune function, inflammatory mediators, and molecules interacting with the lipopolysaccharide recognition complex were obtained from two cohorts of matched children (aged 9.7 ± 1.2 years) from southwest Mexico City (SWMC) (n = 66) and from a control city (n = 93) with criteria pollutant levels below current standards. MC children exhibited significant decreases in the numbers of natural killer cells (p =.003) and increased numbers of mCD14+ monocytes (p <.001) and CD8+ cells (p =.02). Lower concentrations of interferon (p =.009) and granulocyte-macrophage colony-stimulating factor (p <.001), an endotoxin tolerance-like state, systemic inflammation, and an anti-inflammatory response were also present in the highly exposed children. C-reactive protein and the prostaglandin E metabolite levels were positively correlated with twenty-four- and forty-eight-hour cumulative concentrations of PM2.5. Exposure to urban air pollution is associated with immunodysregulation and systemic inflammation in children and is a major health threat. Copyright © 2009 by Society of Toxicologic Pathology.
Colaborador(es) u otros Autores: Macías-Parra M
Hoffmann HJ
Valencia-Salazar G
Henríquez-Roldán C
Osnaya N
Monte OC
Barragán-Mejía G
Villarreal-Calderon R
Romero L
Granada-Macías M
Torres-Jardón R
Medina-Cortina H
Maronpot RR.
Fecha de publicación : 2009
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1177/0192623308329340
Fuente: Toxicologic Pathology 37(2):161 - 169
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2513
Idioma: eng
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