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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2507| Título : | Immunoglobulin Concentrations in Plasma and Saliva during the Neonatal Period |
| Creador: | Pineda Martínez, Sandra |
| Nivel de acceso: | Open access |
| Palabras clave : | Factores de Edad Lactancia Materna Ensayo de Inmunoadsorción Enzimática Femenino Humanos Isotipos de Inmunoglobulinas - metabolismo Recién nacido Masculino Saliva - metabolismo Age Factors Breast Feeding Enzyme-Linked Immunosorbent Assay Female Humans Immunoglobulin Isotypes - metabolism Infant, Newborn Male Saliva - metabolism IgA IgE IgM recién nacido plasma saliva IgA IgE IgM newborn plasma saliva |
| Descripción : | Background Screening for infectious diseases in newborns using immunoglobulin (Ig)A-, IgM-, and IgE-specific antibodies is expensive and impractical. To determine if total levels of these Igs can be used for screening purposes, thus simplifying the process, their basic levels in the 1st month of extrauterine life need to be determined. Additionally, the ability to simplify screening by using saliva also needs to be determined. The aim of this study was to determine IgA, IgM, and IgE concentrations in plasma and saliva in newborns, correlation between the samples, and relationship between Ig levels and newborn age. Methods We enrolled 53 apparently healthy newborns, paired samples of plasma and saliva were collected, and total IgA, IgM, and IgE concentrations determined by capture enzyme-linked immunosorbent assay. The correlation between plasma and saliva values was calculated by Spearman's rank correlation coefficient and the IgA, IgM, and IgE distributions were analyzed by the Shapiro-Wilk test. We also determined the level of each Ig concentration according to age. Results IgA and IgM levels in plasma and IgA levels in saliva increased significantly during 1st month of life, especially in the 2nd week and 3rd week, with a good correlation of IgA between plasma and saliva. IgE levels in both plasma and saliva and IgM levels in saliva were very low or absent. Conclusion These results suggest that Igs in saliva could be good biomarkers for newborn screening programs during the 1st week of life. This study established reference values for Igs according to age in the neonatal period. © 2015, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license. |
| Colaborador(es) u otros Autores: | Hernandez-Islas José Luis Escobedo-Torres Mónica Patricia Paredes-Alonzo Iris Evelin Lopez-Candiani Carlos Correa Dolores Vela-Amieva Marcela |
| Fecha de publicación : | 2016 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1016/j.pedneo.2015.06.005 |
| Fuente: | Pediatrics and Neonatology 57(3):213 - 218 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2507 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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