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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2505| Título : | Immunoendocrine mechanisms associated with resistance or susceptibility to parasitic diseases during pregnancy |
| Creador: | Vargas Villavicencio, José Antonio |
| Nivel de acceso: | Open access |
| Palabras clave : | Formación de Anticuerpos Citocinas - fisiologia Endometrio - inmunologia Feto - inmunologia Regulación de la Expresión Génica Hormonas Esteroides Gonadales - fisiologia Hormonas - fisiologia Interacciones Huésped-Parásitos -inmunologia Interacciones Huésped-Parásitos - fisiologia Inmunidad Celular Subgrupos Linfocitarios - inmunologia Mamíferos - inmunologia Mamíferos - fisiologia Modelos Inmunológicos Parasitemia -inmunologia Parasitemia - fisiopatologia Enfermedades Parasitarias - inmunologia Enfermedades Parasitarias -fisiopatologia Embarazo Complicaciones Infecciosas del Embarazo - inmunologia Complicaciones Infecciosas del Embarazo - parasitologia Complicaciones del Embarazo Infectious -fisiopatologia Antibody Formation Cytokines - physiology Endometrium - immunology Fetus - immunology Gene Expression Regulation Gonadal Steroid Hormones - physiology Hormones - physiology Host-Parasite Interactions - immunology Host-Parasite Interactions - physiology Immunity, Cellular Lymphocyte Subsets - immunology Mammals - immunology Mammals - physiology Models, Immunological Parasitemia - immunology Parasitemia - physiopathology Parasitic Diseases - immunology Parasitic Diseases - physiopathology Pregnancy Pregnancy Complications, Infectious - immunology Pregnancy Complications, Infectious - parasitology Pregnancy Complications, Infectious - physiopathology Infecciones parasitarias de la respuesta inmunológica de embarazo Pregnancy Immune response Parasitic infections |
| Descripción : | During pregnancy, the mammalian endocrine system plays a leading role in maintaining the fetus, characterized by an increase in the level of hormones such as progesterone, oestradiol and some gonadotropic hormones. The immune system participates during pregnancy by self-regulating to prevent fetus rejection. The distinctive type of immunity during gestation is characterized by an increase in levels of Th2 type cytokines IL-4, IL-6 and IL-10, concomitant with a decrease in IL-2, INF-γ and TNF-α levels. Along pregnancy, sex steroids and factors associated with them regulate the immune response. In this way, endocrine and immunologic factors have an impact on the pregnant female's susceptibility or resistance to parasitic diseases. There are three main mechanisms proposed to explain this susceptibility or resistance: (1) sex steroids influence the host's immune system; (2) hormones acting directly on the parasites inhibit or promote their reproduction, or (3) the two effects can occur simultaneously within a network of immuno-endocrine host-parasite interactions, mediated by hormones, cytokines, antibodies and other factors interacting directly and bidirectionally. The present work reviews recent literature concerning the most frequent parasitic infections during pregnancy and discusses the mechanisms implied in the establishment, growth, reproduction or elimination of the parasite. Copyright © 2009 S. Karger AG. |
| Colaborador(es) u otros Autores: | De León-Nava MA Morales-Montor J. |
| Fecha de publicación : | 2009 |
| Tipo de publicación: | Revisión |
| Formato: | |
| Identificador del Recurso : | 10.1159/000180266 |
| Fuente: | NeuroImmunoModulation 16(2):114 - 121 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2505 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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