Identification of CD4+ T cell epitopes of Taenia solium paramyosin

López Moreno HS

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Título :	Identification of CD4+ T cell epitopes of Taenia solium paramyosin
Creador:	López Moreno HS
Nivel de acceso:	Open access
Palabras clave :	Linfocitos T CD4-Positivos - inmunología Cisticercosis - inmunología Epítopos de Linfocito T - química Taenia solium - inmunología Tropomiosina - inmunología CD4-Positive T-Lymphocytes - immunology Cysticercosis - immunology Epitopes, T-Lymphocyte - chemistry Taenia solium - immunology Tropomyosin - immunology Taenia solium paramiosina Epítopo de célula T CD4 + cisticercosis I-Ad Taenia solium paramyosin CD4+ T cell epitope cysticercosis I-Ad
Descripción :	T cell mediated response is involved in a protective immune response against experimental cysticercosis conferred by immunization with Taenia solium paramyosin (TPmy) to BALB/c mice. In this study, we analysed the TPmy amino acid sequence for predicted CD4+ T cells epitopes. Five different regions of this protein showed that the residues anchor to bind the I-A d molecule; synthetic peptides containing these epitopes were evaluated for their ability to induce lymphoproliferative responses of spleen cells from TPmy immunized mice. Among them, Tp176 (amino acids 176-192 sequence DDLQRQMADANSAKSRL) was the immunodominant T cell epitope of TPmy. Delineation of this epitope should facilitate analysis of the role of CD4+ T cell response in experimental cysticercosis.
Colaborador(es) u otros Autores:	Correa D Laclette JP Ortiz-Navarrete VF
Fecha de publicación :	2003
Tipo de publicación:	Artículo
Formato:	pdf
Identificador del Recurso :	10.1111/j.1365-3024.2003.00658.x
Fuente:	Parasite Immunology 25(10):513 - 516
URI :	http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2497
Idioma:	eng
Aparece en las colecciones:	Artículos

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