Growth in children with type 1 diabetes mellitus

Arguinzonis, Lizette

Por favor, use este identificador para citar o enlazar este ítem: http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2468

Título :	Growth in children with type 1 diabetes mellitus
Creador:	Arguinzonis, Lizette
Nivel de acceso:	Open access
Descripción :	Objective Determine growth and development pattern and its disorders in patients with DM-1. Materials & Method We included all patients with DM-1 with more than 6 months of follow-up. Age, gender, age at onset were compared with clinical, anthropometrical and biochemical variables analyzed quarterly: age, time of evolution, weight, height, growth velocity, Tanner puberty score, glucose, HbA1c, cholesterol, and triglycerides. Differences in age at diagnosis, current age, pubertal stage, years of evolution as well as HbA1c, cholesterol and triglycerides averages were paired and analyzed for sex by T test for parametric variables and by Mann-Whitney U test for non-parametric variables. Anthropometrical parameters were compared with Mexican normal growth study. We also compared the dependent variables to identify factors associated with acceleration and deceleration of linear growth with X2 test, Fisher’s test and Spearman correlation. Multivariate analysis was used to identify the most important factor in the slowdown of linear growth and short stature with SPSS software version 10. Considered statistically significant a value less than 0.05 Results 264 patients were included: 116 (43.9%) male and 148 (56%) female, with an average age at diagnosis of 8.5±4.0 years and a mean of 6.1 years of evolution. Comparing our results with Mexican data, there are no significant differences at diagnosis in height or weight in boys, while in girls there is a trend to have a shorter height and higher weight, but comparing the diabetic patients, height at diagnosis was lower in girls than boys (-0.54 vs. 0.14 SD), and weight higher in boys than girls (0.8 vs. 0.2 ED). During evolution the height correlated inversely with HbA1c (r = 0.8, p = 0.000) while weight correlated with height (r = 0.955, p = 0.000). Z score of height decreased during follow-up while weight and BMI did not change significantly. Growth velocity in the group that maintain constant HbA1c <9% increased significantly after the seventh year of evolution compared with the group with constant HbA1c ≥ 9% (6.9±2.3 vs. 4.4±2.1cm/year) (p = 0.003) respectively. We found no significant correlation between growth velocity and changes in mean annual HbA1c if it maintained values lower o higher than 9%. When the patients reached final height, 5.1% of them had short stature. Conclusion Metabolic control has inversely correlated with growth velocity and final height in patients with type 1 diabetes mellitus
Colaborador(es) u otros Autores:	Altamirano Nelly Valderamma Alejandro Montesinos Hortensia Ruiz María de la Luz Goldaracena Francisco Zúñiga Eva Gil Julian Forero Catalina CalzadaLeón Raúl Pérez Mauricio
Fecha de publicación :	2009
Tipo de publicación:	Artículo
Formato:	pdf
Identificador del Recurso :	10.1159/000239668
Fuente:	Horm Res 72(S3):483
URI :	http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2468
Idioma:	eng
Aparece en las colecciones:	Artículos

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