Por favor, use este identificador para citar o enlazar este ítem:
http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2445| Título : | Fresomega and citicholine do not alter Na+K+ATPase, Lipid peroxidation or glutathione levels in the brain of malnourished rats |
| Creador: | Calderón Guzmán, David |
| Nivel de acceso: | Open access |
| Palabras clave : | ATPasa Intercambiadora de Sodio-Potasio |
| Descripción : | This study investigated the effects of Fresomega® (fish oil) and citicholine (cytidine-5′-diphosphocholine; aka. citicoline) on lipid peroxidation (TBARS), glutathione (GSH) levels, and Na+K +ATPase and total ATPase activity in the brain of young rats fed a normal or a protein-deficient diet. Male Wistar rats (21 days old) were fed a normal diet (well-nourished, WN) or a low-protein (7 %) diet (malnourished, MN) and grouped as follows: group I animals (controls) were treated with 0.9 % NaCl; group II with Fresomega® (250 mg/kg), and group III with citicholine (500 mg/kg). Fresomega® and citicholine were administered intraperitoneally (ip) for 30 days. At the end of the study, animals were sacrificed by decapitation and the brain homogenized to measure Na+K+ATPase, total ATPase and TBARS levels by spectrophotometry, while GSH levels were measured by fluorometry. The Hb, Na+K+ ATPase, total ATPase, lipid peroxidation and GSH levels significantly increased (p< 0.05) in all the protein-deficient diet groups compared with normal diet groups. Our results suggest that protein-deficient intake increases oxidative stress but that supplementation with neither Fresomega® nor citicholine at the doses tested can reverse these effects. |
| Colaborador(es) u otros Autores: | Norma Osnaya Brizuela Raquel García Alvarez Gerardo Barragán Mejía Ernestina Hernández García Daniel Santamaría del Angel Mario De la Rosa Apreza Juárez Olguín, Mateo Hugo |
| Fecha de publicación : | 2006 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Fuente: | Proceedings of the Western Pharmacology Society 49():104 - 108 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2445 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.