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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2427| Título : | External membrane vesicles from Helicobacter pylori induce apoptosis in gastric epithelial cells |
| Creador: | Ayala G |
| Nivel de acceso: | Open access |
| Palabras clave : | Apoptosis - fisiología - Humanos Proteínas Bacterianas - metabolismo - Humanos Línea Celular Tumoral - Línea Celular Tumoral - humanos Membrana Celular - ultraestructura - Humanos Medios de Cultivo Condicionados - análisis - humanos Células Epiteliales - microbiología - humanos Células Epiteliales - fisiología - humanos Mucosa Gástrica - citología - humanos Mucosa Gástrica - microbiología - humanos Mucosa Gástrica - fisiología - humanos Helicobacter pylori - patogenecidad - humanos Helicobacter pylori - ultraestructura - humanos Virulencia - fisiología - humanos Apoptosis - physiology - Humans Bacterial Proteins - metabolism - Humans Cell Line, Tumor - Humans Cell Membrane - ultrastructure - Humans Culture Media, Conditioned - analysis - Humans Epithelial Cells - microbiology - Humans Epithelial Cells - physiology - Humans Gastric Mucosa - cytology - Humans Gastric Mucosa - microbiology - Humans Gastric Mucosa - physiology - Humans Helicobacter pylori - pathogenicity - Humans Helicobacter pylori - ultrastructure - Humans Virulence - physiology - Humans Apoptosis Helicobacter VacA Apoptosis Helicobacter VacA |
| Descripción : | The Helicobacter pylori infection of gastric mucosa is one of the most common infectious diseases and is associated with a variety of clinical outcomes, including peptic ulcer disease and gastric cancer. Helicobacter pylori-induced damage to gastric mucosal cells is controlled by bacterial virulence factors, which include VacA and CagA. Outer membrane vesicles are constantly shed by the bacteria and can provide an additional mechanism for pathogenicity by releasing non-secretable factors which can then interact with epithelial cells. The present report shows that external membrane vesicles are able to induce apoptosis not mediated by mitochondrial pathway in gastric (AGS) epithelial cells, as demonstrated by the lack of cytochrome c release with an activation of caspase 8 and 3. Apoptosis induced by these vesicles does not require a classic VacA+ phenotype, as a negative strain with a truncated and therefore non-secretable form of this protein can also induce cell death. These results should be taken into account in future studies of H. pylori pathogenicity in strains apparently VacA- |
| Colaborador(es) u otros Autores: | Torres L. Espinosa M. Fierros-Zarate G. Maldonado V. Melenez-Zajgla J |
| Fecha de publicación : | 2006 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1111/j.1574-6968.2006.00305.x |
| Fuente: | Fems Microbiol Lett 260(2):178-185 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2427 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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