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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2418| Título : | Expression of CD34, Ki-67, p53 and cytokeratin AE1/AE3 in solid and adenoid basal cell carcinoma |
| Creador: | Cuevas González MV |
| Nivel de acceso: | Open access |
| Palabras clave : | Adenoid; Basal cell carcinoma; Immunohistochemistry panel; Solid |
| Descripción : | BACKGROUND: The basal cell carcinoma (BCC) is a very common heterogeneous malignant neoplasm, its histopathology has a strong similarity with some benign neoplasms of follicular origin; therefore it is necessary to establish a correct diagnosis. OBJECTIVE: To determine the expression of immunohistochemical markers CK AE1/AE3, p53, Ki-67 and CD34 in solid and adenoid basal cell carcinoma. MATERIAL AND METHOD: A descriptive study (N=59) was done; paraffin-embedded tissue blocks with diagnosis of BCC were included, n=39 solid type and n=20 adenoid type, the immunohistochemistry technique with antibodies CK AE1/AE3, p53, Ki-67 and CD34 was performed, the results were analyzed semi-quantitatively by two examiners previously standardized assessing the intensity and quantity expression of each marker. RESULTS: The expression of CK AE1-AE3 was of 100% in intensity and quantity in both histopathological subtypes, the marker CD34 in solid BCC was presented predominantly in the stroma below the lesion, in the adenoid CBC it was expressed between the nests of the neoplasm, the antibodies CK AE1/AE3, p53, CD34 and Ki-67 had not significant differences in their localization. CONCLUSIONS: While p53 and Ki-67 are very helpful to determine the prognosis of the neoplasm, they are not decisive when it comes to differentiate between histopathological subtypes of BCC; on the contrary, CD34 could be useful as a marker to help distinguish between histopathological subtypes, this due to the topographical differences expressed between both neoplasms. |
| Colaborador(es) u otros Autores: | Vega-Memije ME Cuevas-González JC García- Vázquez FJ Cháirez-Atienzo P Ávila-Valdez R |
| Fecha de publicación : | 2016 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Fuente: | Dermatologia Revista Mexicana 60(4):311 - 318 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2418 |
| Idioma: | spa |
| Aparece en las colecciones: | Artículos |
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