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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2403| Título : | Evaluation of the mutagenic and antimutagenic activities of saffron |
| Creador: | Hernández JM |
| Nivel de acceso: | Open access |
| Palabras clave : | Crocus sativus - Análisis Crocus sativus - Analysis Antimutagenicidad Crocus sativus L. Mutagenicidad Antimutagenicity Crocus sativus L. Mutagenicity |
| Descripción : | We have analyzed the mutagenic and antimutagenic activities of different concentrations of aqueous and alcoholic saffron extracts, by using classic Ames/Salmonella typhimurium assay With strains TA98 or TA100 and two well-known mutagens: 2-aminoantrhracene (2-AA) and benzo(a)pyrene (B(a)P). Our results indicated that under conditions tested (50-1500 μg/ml) saffron did not display mutagenic, antimutagenic or toxic effects on bacterial strains used. Saffron extracts were unable to modify the number of mutant colonies induced by B(a)P, but in case of 2-AA, we observed a dose-dependent co-mutagenic effect of saffron. Results of experiments with isolated ingredients of saffron showed that the responsible molecule for this unusual co-mutagenic effect of saffron was safranal. The molecular basis for the observed differential effects of saffron on B(a)P and 2-AA induced mutagenesis is currently under investigation. Taken together, our results indicate that saffron extract itself is non-toxic, and non-mutagenic and can be considered as a potential cancer chemopreventive agent. |
| Colaborador(es) u otros Autores: | Abdullaev FI Caballero Ortega H Riverón Negrete L Pérez López I Medécigo Ríos M |
| Fecha de publicación : | 2004 |
| Tipo de publicación: | Otros |
| Formato: | |
| Identificador del Recurso : | 10.17660/ActaHortic.2004.650.57 |
| Fuente: | Acta Horticulturae 650(1):471-475 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2403 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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