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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2393| Título : | Elevated plasma endothelin-1 and pulmonary arterial pressure in children exposed to air pollution |
| Creador: | Calderón Garcidueñas, Lilian |
| Nivel de acceso: | Open access |
| Palabras clave : | Contaminantes del Aire - análisis - child Contaminantes del Aire - toxicidad - child Contaminantes del Aire - adversos efectos - child Contaminantes del Aire - análisis - child Presión Sanguínea - efectos de drogas Ecocardiografía Doppler - child Endotelina-1 - sangre - child Recuento de Leucocitos - child Neutrófilos - efectos de drogas - child Ozono - análisis - child Ozono - toxicidad - child Material Particulado - análisis - child Material Particulado - toxicidad - child Arteria Pulmonar - efectos de drogas - child Arteria Pulmonar - Fisiopatología - child Air Pollutants - analysis - child Air Pollutants - toxicity - child Air Pollution - adverse effects - child Blood Pressure - drug effects - child Echocardiography, Doppler - child Endothelin-1 - blood - child Leukocyte Count - child Neutrophils - drug effects - child Ozone - analysis - child Ozone -toxicity - child Particulate Matter - analysis - child Particulate Matter - toxicity - child Pulmonary Artery - drug effects - child Pulmonary Artery - physiopathology - child air pollution endothelial dysfunction endothelin-1 children particulate matter pulmonary arterial pressure |
| Descripción : | Background: Controlled exposures of animals and humans to particulate matter (PM) or ozone air pollution cause an increase in plasma levels of endothelin-1, a potent vasoconstrictor that regulates pulmonary arterial pressure. Objectives: The primary objective of this field study was to determine whether Mexico City children, who are chronically exposed to levels of PM and O3 that exceed the United States air quality standards, have elevated plasma endothelin-1 levels and pulmonary arterial pressures. Methods: We conducted a study of 81 children, 7.9 ± 1.3 years of age, lifelong residents of either northeast (n = 19) or southwest (n = 40) Mexico City or Polotitlán (n = 22), a control city with PM and O3 levels below the U.S. air quality standards. Clinical histories, physical examinations, and complete blood counts were done. Plasma endothelin-1 concentrations were determined by immunoassay, and pulmonary arterial pressures were measured by Doppler echocardiography. Results: Mexico City children had higher plasma endothelin-1 concentrations compared with controls (p < 0.001). Mean pulmonary arterial pressure was elevated in children from both northeast (p < 0.001) and southwest (p < 0.05) Mexico City compared with controls. Endothelin-1 levels in Mexico City children were positively correlated with daily outdoor hours (p = 0.012), and 7-day cumulative levels of PM air pollution < 2.5 μm in aerodynamic diameter (PM2.5) before endothelin-1 measurement (p = 0.03). Conclusions: Chronic exposure of children to PM2.5 is associated with increased levels of circulating endothelin-1 and elevated mean pulmonary arterial pressure. |
| Colaborador(es) u otros Autores: | Vincent R Mora-Tiscareño A Franco-Lira M Henríquez-Roldán C Barragán-Mejía G Garrido-García L Camacho-Reyes L Valencia-Salazar G Paredes R Romero L Osnaya H Villarreal-Calderón R Torres-Jardón R Hazucha MJ Reed W. |
| Fecha de publicación : | 2007 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1289/ehp.9641 |
| Fuente: | Environmental Health Perspectives 115(8):1248 - 1253 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2393 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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