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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2390| Título : | EGb761 blocks MPP+-induced lipid peroxidation in mouse corpus striatum |
| Creador: | Rojas, Patricia |
| Nivel de acceso: | Open access |
| Palabras clave : | 1-metil-4-fenilpiridinio - farmacología Animales Cuerpo estriado - fisiología Ginkgo biloba - Peroxidación de Lípido - efectos de drogas Neurotoxinas - toxicidad Extractos vegetales - farmacología Methyl 4 phenylpyridinium - pharmacology Animals Corpus Striatum - physiology Ginkgo biloba Lipid Peroxidation - drug effects Neurotoxins - toxicity Plant Extracts - pharmacology MPP1 Peroxidación lipídica neuroprotección enfermedad de Parkinson EGb761 MPP1 lipid peroxidation neuroprotection parkinson’s disease EGb761 |
| Descripción : | EGb761 has been suggested to be an antioxidant and free radical scavenger. Excess generation of free radicals, leading to lipid peroxidation (LP), has been proposed to play a role in the damage to striatal neurons induced by 1-methyl-4-phenylpyridinium (MPP+). We investigated the effects of EGb761 pretreatment on MPP+ neurotoxicity. C-57 black mice were pretreated with EGb761 for 17 days at different doses (0.63, 1.25, 2.5, 5 or 10 mg/kg) followed by administration of MPP+, (0.18, 0.36 or 0.72 mg/kg). LP was analyzed in corpus striatum at 30 min, 1 h, 2 h and 24 h after MPP+ administration. Striatal dopamine content was analyzed by HPLC at the highest EGb761 dose at 2 h and 24 h after MPP+ administration. MPP+-induced LP was blocked (100%) by EGb761 (10 mg/kg). Pretreatment with EGb761 partially prevented (32%) the dopamine-depleting effect of MPP+ at 24 h. These results suggest that supplements of EGb761 may be effective at preventing MPP+-induced oxidative stress. |
| Colaborador(es) u otros Autores: | Garduño Belén Rojas Carolina Vigueras Rosa María Rojas Castañeda Julio Ríos Camilo Serrano Garcia Norma |
| Fecha de publicación : | 2001 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1023/A:1013971524150 |
| Fuente: | Neurochemical Research 26(11):1245 - 1251 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2390 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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