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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2381| Título : | Effects of two new steroids and cyproterone on some biomarkers of oxidative stress and serotonergic system on rat prostate and brain |
| Creador: | Calderón GD |
| Nivel de acceso: | Open access |
| Palabras clave : | Biomarcadores - análisis - ratas Encéfalo - efectos de drogas - ratas Encéfalo - metabolismo - ratas Acetato de Ciproterona - farmacología Glutatión - metabolismo - ratas Ácido Hidroxiindolacético -metabolismo - ratas Estrés Oxidativo - efectos de drogas - ratas Estrés Oxidativo - fisiología - ratas Pregnatrienos - farmacología - ratas Pregnenolona - análogos & derivados - ratas Pregnenolona - farmacología - ratas Prostate - efectos de drogas - ratas Prostate - ratas Serotonina - fisiología - ratas ATPasa Intercambiadora de Sodio-Potasio - metabolismo - ratas Biomarkers - analysis - rats Brain - drug effects - rats Brain - metabolism - rats Cyproterone Acetate - pharmacology - rats Glutathione - metabolism - rats Hydroxyindoleacetic Acid - metabolism - rats Oxidative Stress - drug effects - rats Oxidative Stress - physiology -rats Pregnatrienes - pharmacology - rats Pregnenolone - analogs & derivatives - rats Pregnenolone - pharmacology - rats Prostate - drug effects - rats Prostate - metabolism - rats Serotonin - physiology - rats Sodium-Potassium-Exchanging ATPase - metabolism - rats Thiobarbituric Acid Reactive - rats cerebro, radicales libres, glutatión, próstata, esteróides Brain—free radicals—glutathione— prostate—steroids |
| Descripción : | The purpose of this study was to evaluate the effect of cyproterone acetate (CPA, A) compared with new synthetic steroids 3α-acetoxy-5,6-epoxy-16- pregnen-20-one (B) and 17α-hydroxy-16β-methyl-1,4,6-pregnatriene-3, 20-dione (C) in rat prostate and brain. Groups of animals were treated either with A, B or C (4 mg kg-1day-1) by the intraperitoneal route for 5 days. Levels of reduced glutathione (GSH), 5-hydroxy-indole acetic acid (5-HIAA), lipid peroxidation (as thiobarbituric acid reactive substances, TBARS) and the activities of Na+, K+- and total ATPases were assayed in prostate and brain for each group of animals including a control group. No appreciable changes were shown in Na+, K +-ATPase and total ATPases and TBARS on prostate and brain of rats that received A, B and C steroids. However, the levels of GSH and 5-HIAA decreased significantly (P < 0.05) in both tissues for the steroids assayed. It is concluded that CPA and the homologues B and C steroids induce changes in the levels of GSH and serotonin in rat prostate and brain. © 2009 Blackwell Publishing Ltd. |
| Colaborador(es) u otros Autores: | Bratoeff E Ramírez LE Osnaya BN García AR Barragán MG Hernández GE Juárez OH |
| Fecha de publicación : | 2009 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1111/j.1439-0272.2008.00886.x |
| Fuente: | Andrologia 41(1):29 - 34 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2381 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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