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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2380| Título : | Effects of oxcarbazepine on the behavioral response and neuroanatomical alterations following administration of kainic acid |
| Creador: | Gonzalez Maciel, Angelica |
| Nivel de acceso: | Open access |
| Palabras clave : | Anticonvulsivantes - farmacología Conducta Animal - efectos de drogas Carbamazepina - análogos y derivados Carbamazepina - farmacología Agonistas de Aminoácidos Excitadores - farmacología Hipocampo - fisiopatología Ácido Kaínico - farmacología Ácido Kaínico - administración y dosificación Ácido Kaínico - antagonistas e inhibidores Sistema Nervioso - efectos de drogas Sistema Nervioso - patología Convulsiones - inducido químicamente Convulsiones - patología Convulsiones prevención y control Ratas Anticonvulsants -pharmacology Behavior, Animal - drug effects Carbamazepine - analogs & derivatives Carbamazepine -pharmacology Excitatory Amino Acid Agonists - pharmacology Hippocampus - physiopathology Kainic Acid - pharmacology Kainic Acid - administration & dosage Kainic Acid - antagonists & inhibitors Nervous System - drug effects Nervous System - pathology Seizures - chemically induced Seizures - pathology Seizures - prevention & control Rats Carbamazepina Ácido Kaínico farmacología Anticonvulsivantes Sistema Nervioso Carbamazepine Kainic Acid pharmacology Anticonvulsants Nervous System |
| Descripción : | Epilepsy is considered to be a disorder intrinsic to the brain, deriving from either a hereditary tendency or a prior insult, in which a portion of the brain is rendered electrically unstable [1]. Temporal lobe epilepsy is the most devastating form of epilepsy commonly encountered in the adult population. The attacks involve loss of consciousness, thus limiting performance of normal functions and exposing the individual to bodily injury. Moreover, long-standing or pharmacologically intractable temporal lobe epilepsy is frequently associated with the loss of neurons from the hippocampus and other brain regions [2-4] Unfortunately, pharmacologically intractable cases are rather common, owing to the relatively low efficacy against this condition of the available anticonvulsants. As ethical considerations rule out use of the modern neuroscientific tools in intact human brain, the study of epilepsy has been dependent upon use of model systems. Much of what is known about the epilepsy is derived from animal models [5]. Basic models of epilepsy have been used to explore questions about seizures and the electrical activity of the brain. These questions are related to the underlying EEG generators of electrical potentials associated with seizures: the nature and identity of neuronal systems able to produce epilepsy; issues of why seizures start, spread and stop, and why seizures occur when they do; what type of pathologies in brain give rise to seizures; whether seizures cause damage to brain; and the mechanisms of action of anticonvulsant drugs [6-8]. |
| Colaborador(es) u otros Autores: | Reynoso Robles R Romero RM Huerta B González V Vargas L Ayala Guerrero F. |
| Fecha de publicación : | 2000 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Fuente: | Proceedings of the Western Pharmacology Society 43():35-37 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2380 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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