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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2379| Título : | Effects of nociceptin on the spread and seizure activity in the rat amygdala kindling model: Their correlations with 3H-leucyl-nociceptin binding |
| Creador: | Carmona Aparicio, Liliana |
| Nivel de acceso: | Open access |
| Palabras clave : | Amígdala del Cerebelo - efectos de drogas Amígdala del Cerebelo - Fisiopatología Encéfalo - efecto de drogas Encéfalo - metabolismo Electrodos Implantados Epilepsias Parciales - Fisiopatología Epilepsia Generalizada - Fisiopatología Excitación Neurológica - efectos de drogas Péptidos Opioides - metabolismo Péptidos Opioides - farmacología Ratas Wistar Convulsiones - Fisiopatología Amygdala - drug effects - rats Amygdala - physiopathology - rats Brain - drug effects Brain -metabolism Electrodes, Implanted - rats Epilepsies, Partial - physiopathology - rats Epilepsy, Generalized - physiopathology - rats Kindling, Neurologic - drug effects - rats Opioid Peptides - metabolism - rats Opioid Peptides - pharmacology - rats Rats, Wistar Seizures - physiopathology - rats Nociceptin Nociceptin receptor Afterdischarge threshold Postictal depression Kindling |
| Descripción : | The effects with pretreatment with nociceptin (0.03—30 nmol, i.c.v.) were evaluated on the threshold for eliciting afterdischarge (ADT), generation and spread of seizure activity and postictal depression in rats with kindling stimulation. Nociceptin produced a decrease in ADT (32—45%) in rats with partial seizures (PS, stage II—III), and an increase (61—92%) in rats with generalized seizures (GS, kindled state). Nociceptin did not modify the behavioral changes, spike frequency and duration of afterdischarge elicited at ADT in both experimental groups. In rats with GS, nociceptin enhanced postictal depression (34—44%) evaluated with a recycling paradigm. Autoradiography experiments revealed enhanced nociceptin opioid receptor (NOP) binding in medial amygdala (22—26%), frontal (21—23%) and entorhinal (27—32%) cortices, and reduced binding in the substantia nigra pars compacta (28%) and medial central gray (29%) of rats with PS. The GS group displayed significant decreased NOP binding (40—70%) in most of the brain areas evaluated. These results suggest that nociceptin facilitates ictal activity in rats with PS, whereas in animals with GS, it induces inhibitory effects on ADT and enhances the postictal period. These effects correlate with significant changes in NOP binding. © 2007 Elsevier B.V. All rights reserved. |
| Colaborador(es) u otros Autores: | Fernando Peña Anna Borsodi Luisa Rocha |
| Fecha de publicación : | 2007 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1016/j.eplepsyres.2007.08.007 |
| Fuente: | Epilepsy Res 77(2-3):75-84 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2379 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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