Por favor, use este identificador para citar o enlazar este ítem: http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2372
Título : Effects of cyclosporin-A on immune response, tissue protection and motor function of rats subjected to spinal cord injury
Creador: Ibarra A
Nivel de acceso: Open access
Palabras clave : Ciclosporina - farmacología
Inmunosupresores - farmacología
Actividad Motora - Efectos de drogas
Médula Espinal - Patología
Compresión de la Médula Espinal - Quimioterapia
Compresión de la Médula Espinal - Patología
Cyclosporine - pharmacology
Immunosuppressive Agents - pharmacology
Motor Activity - drug effects
Spinal Cord - pathology
Spinal Cord Compression - drug therapy
Spinal Cord Compression- pathology
Autoinmunidad
Respuesta celular
Desmielinización
Neuroprotección
Paraplegia
Autoimmunity
Cellular response
Demyelination
Neuroprotection
Paraplegia
Descripción : The aim of this work was to test the effect of cyclosporin-A (CsA) on some immunological, morphological and functional aspects developed after spinal cord injury. The specific cellular immune response against spinal cord constituents, the amount of spared tissue and myelination at the site of injury, and the motor function outcome were assessed in a first series of experiments. Rats were subjected to spinal cord compression and treated with cyclosporin-A before lesion and during the entire study. A specific lymphocyte response against spinal cord antigens was found in untreated spinal cord injured rats but not in cyclosporine-A treated injured rats. A significantly better myelination index was also found in injured cyclosporin-A-treated rats, as compared to untreated animals. The amount of spared spinal cord tissue at the epicenter was not significantly different comparing CsA-treated with vehicle-treated rats. Looking for a potential therapeutic use of CsA, in a second series of experiments, rats were subjected to spinal cord contusion and treated with cyclosporin-A from 1 to 72 h after lesion. Motor recovery and red nuclei neurons survival, were evaluated, and found to be significantly better in spinal cord injured rats treated with cyclosporin-A than in injured-untreated rats. This work confirms the existence of an autoimmune cellular reaction after injury that can be inhibited by cyclosporin-A treatment. Furthermore, cyclosporin-A promotes neuroprotection by diminishing both demyelination and neuronal cell death, resulting in a better motor outcome after spinal cord injury. © 2003 Elsevier B.V. All rights reserved.
Colaborador(es) u otros Autores: Correa D
Willms K
Merchant MT
Guizar-Sahagún G
Grijalva I
Madrazo I
Fecha de publicación : 2003
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1016/S0006-8993(03)02898-1
Fuente: Brain Research 979(1 y 2):165-178
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2372
Idioma: eng
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