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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2368| Título : | Effects of a Cyclooxygenase-2 Preferential Inhibitor in Young Healthy Dogs Exposed to Air Pollution: A Pilot Study |
| Creador: | Calderón Garcidueñas, Lilian |
| Nivel de acceso: | Open access |
| Palabras clave : | Contaminación del Aire - efectos adversos - perros - México Péptidos beta-Amiloides - metabolismo - perros - México Acuaporina 4 - metabolismo - perros - México Ciclooxigenasa 2 - genética - perros - México Ciclooxigenasa 2 - metabolismo - perros - México Inhibidores de la Ciclooxigenasa 2 - farmacocinética - perros - México Inhibidores de la Ciclooxigenasa 2 - framacología - perros - México perros - metabolismo - México Lóbulo Frontal - metabolismo - perros - México Inmunohistoquímica - perros - México Interleucina-1beta - genética - perros - México Interleucina-1beta - metabolismo - perros - México Imagen por Resonancia Magnética - perros - México Mucosa Nasal - metabolismo - perros - México Ozono - efectos adversos - perros - México Proyectos Piloto - perros - México Prostaglandins E - metabolismo - perros - México Sulfonamidas - farmacocinética - perros - México Sulfonamidas - farmacología - perros - México Sulfonamidas - líquido cefalorraquídeo - perros - México Tirosina - metabolismo - perros - México Air Pollution - adverse effects - dogs - Mexico Amyloid beta-Peptides - metabolism - dogs - Mexico Antigens, CD14 - metabolism - dogs - Mexico Aquaporin 4 - metabolism - dogs - Mexico Cyclooxygenase 2 - genetics - dogs - Mexico Cyclooxygenase 2 - metabolism - dogs - Mexico Cyclooxygenase 2 Inhibitors - pharmacokinetics - dogs - Mexico Cyclooxygenase 2 Inhibitors - pharmacology - dogs - Mexico Dogs - metabolism Frontal Lobe - metabolism - dogs - Mexico Immunohistochemistry - dogs - Mexico Interleukin-1beta - genetics - dogs - Mexico Interleukin-1beta - metabolism - dogs - Mexico Magnetic Resonance Imaging - dogs - Mexico Nasal Mucosa - metabolism - dogs - Mexico Ozone - adverse effects - dogs - Mexico Pilot Projects - dogs - Mexico Prostaglandins E -metabolism - dogs - Mexico Sulfonamides - pharmacokinetics - dogs - Mexico Sulfonamides - pharmacology - dogs - Mexico Sulfonamides - cerebrospinal fluid - dogs - Mexico Tyrosine - metabolism - dogs - Mexico Enfermedad de Alzheimer, contaminación del aire, neuroinflamación, neuropretección, Nimesulide1, líquido cefalorraquídeo, perros, cerebro MRI Alzheimer’s disease; air pollution; neuroinflammation; neuroprotection; Nimesulide1; cerebrospinal fluid; dogs; brain MRI |
| Descripción : | Residency in cities with high air pollution is associated with neuroinflammation and neurodegeneration in healthy children, young adults, and dogs. Nonsteroidal anti-inflammatory drugs may offer neuroprotection. The authors measured the plasma concentrations of 3-nitrotyrosine and the cerebro-spinal-fluid concentrations of prostaglandin E2 metabolite and the oligomeric form of amyloid derived diffusible ligand; measured the mRNA expression of cyclooxygenase-2, interleukin 1β, CD14, and Aquaporin-4 in target brain areas; and evaluated brain MRI, cognition, and neuropathology in 8 dogs treated with a preferential cyclooxygenase-2 inhibitor (Nimesulide®) versus 7 untreated litter-matched Mexico City dogs. Nimesulide® significantly decreased nitrotyrosine in plasma (p < 0001), frontal gray IL1β (p = 03), and heart IL1β (p = 02). No effect was seen in mRNA COX2, amyloid, and PGE2 in CSF or the MRI white matter lesions. All exposed dogs exhibited olfactory bulb and frontal accumulation of Aβ42 in neurons and blood vessels and frontal vascular subcortical pathology. White matter hyperintense MRI frontal lesions were seen in 4/6 non-treated and 6/8 treated dogs. Nonsteroidal anti-inflammatory drugs may offer limited neuroprotection in the setting of severe air pollution exposures. The search for potentially beneficial drugs useful to ameliorate the brain effects of pollution represents an enormous clinical challenge. © 2009, SAGE Publications. All rights reserved. |
| Colaborador(es) u otros Autores: | Mora-Tiscareño A Gómez-Garza G Carrasco-Portugal Mdel C Pérez-Guillé B Flores-Murrieta FJ Pérez-Guillé G Osnaya N Juárez-Olguín H Monroy ME Monroy S González-Maciel A Reynoso-Robles R Villarreal-Calderon R Patel SA Kumarathasan P Vincent R Henríquez-Roldán C Torres-Jardón R Maronpot RR. |
| Fecha de publicación : | 2009 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1177/0192623309340277 |
| Fuente: | Toxicologic Pathology 37(5):644 - 660 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2368 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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