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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2353| Título : | Effect of toluene and nutritional status on serotonin, lipid peroxidation levels and NA+/K+-ATPase in adult rat brain |
| Creador: | Coballase Urritia, Elvia |
| Nivel de acceso: | Open access |
| Palabras clave : | 5-Hidroxitriptófano Peroxidación de Lípido Estado Nutricional Tolueno ATPasa Intercambiadora de Sodio-Potasio Ratas Cerebro - efectos de drogas 5-Hydroxytryptophan Lipid Peroxidation Nutritional Status Toluene Sodium-Potassium-Exchanging ATPase Rats Brain - Drugs effects 5-hidroxitriptófano peroxidación de los lípidos Estado nutricional Serotonina Tolueno 5-Hydroxytryptophan lipid peroxidation Nutritional status Serotonin Toluene |
| Descripción : | The aim was to evaluate the effect of toluene and nutritional status on levels of serotonin (5-HT), 5-hydroxytryptophan (5-HTP), Na+/K +-ATPase, total ATPase and lipid peroxidation (TBARS) in rat brain. Study was conducted with malnourished (MN), well-nourished (WN) and normal Wistar rats. Three groups were formed for each nutritional status: control group I received 0.9% NaCl; toluene (1 g/kg) was administered to group II, and 1.5 g/kg to group III. Levels of 5-HT decreased (P < 0.05) in WN toluene groups, and 5-HTP decreased (P < 0.05) in the WN 1 g toluene and MN 1.5 g toluene groups. TBARS decreased (P < 0.05) in WN toluene groups. A trend to increase in Na+/K+-ATPase was found in WN and MN toluene groups, while total ATPase increased (P < 0.05) in the WN 1.5 g toluene group. The results suggest that high concentrations of toluene in single doses induce significant changes in the serotonergic system and alter membrane fluidity more perceptibly in the brain of adult animals with regular diet than in malnourished animals. © 2005 Springer Science+Business Media, Inc. |
| Colaborador(es) u otros Autores: | Calderón Guzmán David Espitia Vázquez Ivonne López Domínguez Alejandra Hernánez Mejía Ernestina Huerta Gertrudis Bernardino Coballase Urrutia Elvia Juárez Olguín Hugo García Fernández Beatriz |
| Fecha de publicación : | 2005 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1007/s11064-005-2749-2 |
| Fuente: | Neurochemical Research 30(5):619 - 624 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2353 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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