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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2350| Título : | Effect of testosterone and steroids homologues on indolamines and lipid peroxidation in rat brain |
| Creador: | Calderón Guzmán, David |
| Nivel de acceso: | Open access |
| Palabras clave : | Testosterona Esteroides Peroxidación de Lípido - efectos de drogas Ratas Cerebro - efectos de drogas Testosterone Steroids Lipid Peroxidation - drug effects Rats Brain - drug effects Cerebro Peroxidación de los lípidos Serotonina Esteroides Testosterona Brain Lipid peroxidation Serotonin Steroids Testosterone |
| Descripción : | The purpose of the present study was to evaluate the effect of 4-pregnen-17-hydroxy-3-one (A) and two steroids homologues: 3β-acetoxy-5, 16-pregnadien-20-one (B) and 3β-acetoxy-16α-17α-epoxy-4- pregnen-20-one (C). Male Wistar rats were treated with o-cresol combined (A, B or C) steroids. Lipid peroxidation status as result of measurement reactive substances to thiobarbituric acid (TBARS) as well as serotonin (5-HT) and its precursor 5-hydroxytryptophan (5-HTP) were measured. The prostate glands were weighed, the 5α-reductase activity was determined. The animals treated with A, B, and C steroids showed a slight increase in both 5α-reductase activity and prostate size. 5-HT and 5-HTP levels did not change significantly, and TBARS showed an increase in the group treated with B steroid and a decrease in the A steroid group with significant differences in both groups (p < 0.05) versus control group. Results suggest that A steroid reduces TBARS in rat brain, perhaps as a result of the interaction between the testosterone unsaturated carbons and OH- groups with free radicals. © 2004 Elsevier Ltd. All rights reserved. |
| Colaborador(es) u otros Autores: | Barragan Mejía Gerardo Espitia Vazquez Ivonne Hernández García Ernestina Santamaría del Angel Daniel Juarez Olguín Hugo |
| Fecha de publicación : | 2005 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1016/j.jsbmb.2004.11.006 |
| Fuente: | Journal of Steroid Biochemistry and Molecular Biology 94(4):369 - 373 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2350 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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