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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2349| Título : | Effect of sibutramine on Na+, K+ ATPase activity and tryptophan levels on male and female rat brain. |
| Creador: | Guzman, David C |
| Nivel de acceso: | Open access |
| Palabras clave : | Encéfalo - efectos de drogas - ratas Encéfalo - enzimología - ratas Encéfalo - metabolismo - ratas Ciclobutanos - administración & dosificación - ratas Radicales Libres - metabolismo - ratas peroxidación de lípido - efectos de drogas - ratas Distribución Aleatoria Ratas Wistar Caracteres Sexuales ATPasa Intercambiadora de Sodio-Potasio - genética - ratas ATPasa Intercambiadora de Sodio-Potasio - metabolismo - ratas Triptófano - metabolismo - ratas Brain - drug effects - rats Brain - enzymology - rats Brain - metabolism - rats Cyclobutanes - administration & dosage - rats Free Radicals - metabolism - rats Lipid Peroxidation - drug effects - rats Random Allocation Rats, Wistar Sex Characteristics Sodium-Potassium-Exchanging ATPase - genetics - rats Sodium-Potassium-Exchanging ATPase - metabolism - rats Tryptophan - metabolism - rats obesidad, radicales libres, ATPasa, triptófano, cerebro obesity - free radicals - ATPase - tryptophan - brain |
| Descripción : | Some drugs that are clinically used in weight control, like sibutramine, act on the serotonergic metabolism, but its relation with free radical (FR) production in the CNS is still unknown. The aim of the work was to evaluate the effect of sibutramine on FR production. Female and male Wistar rats (250 g weight) were used; the animals received sibutramine (10 mg/kg each 36 hours) intraperitoneally during 15 days. At the end of the study, the rats were sacrificed and their brains used to measure lipid peroxidation (TBARS), Na+, K+ ATPase activity, reduced glutathione (GSH), and tryptophan (TRP) levels, by means of validated methods. The activity of Na+, K+ATPase and total ATPase was increased in males and decreased in females. GSH concentration was increased and the levels of TBARS decreased by an effect related to sibutramine in the female group. Sibutramine decreased TRP concentration in the female group, but increased it in the male one, with respect to the control group. Our results suggest that sibutramine produce an antioxidant effect stimulated by the endogenously produced tryptophan and it protects the fluidity of plasma membrane in rat brain. |
| Colaborador(es) u otros Autores: | Ruíz NL García EH Mejía GB Téllez PP Jimenez GE De la Rosa Apreza M Olguín HJ |
| Fecha de publicación : | 2009 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1055/s-0028-1128145 |
| Fuente: | Hormone and Metabolic Research 41(5):363 - 367 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2349 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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