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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2343| Título : | A simple method to measure plasma levels of propafenone with fluorescence detection |
| Creador: | Flores Pérez, Carmen |
| Nivel de acceso: | Open access |
| Palabras clave : | Cromatografía de Fase Inversa Propafenone - farmacocinética Plasma propafenone; article; blood level; child; correlation coefficient; drug determination; fluorescence; heart failure; human; liquid chromatography; patient satisfaction; priority journal; reversed phase liquid chromatography; sample; separation technique Columna de cromatografía líquida Farmacocinética Niveles plasmáticos Propafenona Column liquid chromatography Pharmacokinetics Plasma levels Propafenone |
| Descripción : | The aim of the present study was to develop a simple method to measure plasma levels of propafenone by liquid chromatography with a C18 reverse-phase column and fluorescence detection, without previous derivatization of the sample. Linearity was assessed in the range from 50 to 1000 ng mL-1 and had a correlation coefficient of 0.999. The inter- and intra-day coefficients of variation were below 5%. The limits of detection and quantification were 15 ng mL-1 and 50 ng mL-1, respectively. Drug levels were determined satisfactorily in two patients. A simple and reliable method was developed, especially useful in children with heart failure under treatment with propafenone. © 2005 Friedr. Vieweg & Sohn/GWV Fachverlage GmbH. |
| Colaborador(es) u otros Autores: | Juárez Olguín Hugo Flores Pérez J. Ramírez-Mendiola B. Bobadilla Chávez J. Bobadilla Chavez J |
| Fecha de publicación : | 2005 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1365/s10337-005-0650-4 |
| Fuente: | Chromatographia 62(7):373-377 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2343 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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