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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2327| Título : | Effect of ivelip and sodium nitroprusside on 5-HT, glutathione and lipid peroxidation in normal and malnourished rat brain |
| Creador: | Calderón Guzmán, David |
| Nivel de acceso: | Open access |
| Palabras clave : | Peso Corporal - efectos de drogas - ratas Química Encefálica - efectos de drogas - ratas Emulsiones Grasas Intravenosas - farmacología - ratas Glutatión - metabolismo - ratas Peroxidación de Lípido - efectos de drogas - ratas Desnutrición - metabolismo - ratas Nitroprusiato - farmacología - ratas Oxidación-Reducción - ratas Estrés Oxidativo - efectos drogas - ratas Desnutrición Proteico-Calórica - metabolismo - ratas Ratas Wistar Serotonina - metabolismo - ratas Aceite de Soja - farmacología - ratas Triglicéridos - farmacología - ratas Triptófano - metabolismo - ratas Body Weight - drug effects - rats Brain Chemistry - drug effects - rats Fat Emulsions, Intravenous - pharmacology - rats Glutathione - metabolism - rats Lipid Peroxidation - drug effects - rats Malnutrition - metabolism - rats Nitroprusside - pharmacology - rats Oxidation-Reduction - rats Oxidative Stress - drug effects - rats Protein-Energy Malnutrition - metabolism - rats Rats, Wistar Serotonin - metabolism - rats Soybean Oil - pharmacology - rats Triglycerides - pharmacology - rats Tryptophan - metabolism - rats |
| Descripción : | We examined the effect of experimental malnutrition and diet supplementation of parameters of central nervous system damage. Wistar rats were fed during 30 days and classified as malnourished (MN, 7% protein content diet) or well-nourished (WN, 23% protein content diet), were grouped and treated as follows: I-control; II-SNP (20 μg/kg); III-Ivelip (280 mg/kg) and IV-Ivelip + sodium nitroprusside (SNP). Levels of lipid peroxidation (TBARS), glutathione (GSH), tryptophan (Trp) and serotonin (5-HT) were assessed in brain by liquid chromatography. TBARS and GSH levels increased significantly (p<0.05) in MN vs. WN rats that did not receive Ivelip. No significant differences were observed in TBARS and GSH among rats that received Ivelip or SNP. The weight of rats decreased significantly (p<0.05) in all MN groups in relation to the WN groups. Hemoglobin (Hb) levels increased significantly (p<0.05) in MN and WN groups that received Ivelip. 5-HT levels increased significantly (p<0.05) in all MN groups. Trp levels increased significantly (p<0.05) in the WN + Ivelip group vs. control. Early malnutrition induces changes in the metabolism of biogenic amines and this condition may promote oxidative injury of the brain. |
| Colaborador(es) u otros Autores: | Ivonne Espitia Vázquez Gerardo Barragán Mejía Norma Osnaya Brizuela Ernestina Hernández García Hugo Juárez-Olguín |
| Fecha de publicación : | 2007 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Fuente: | Proceedings of the Western Pharmacology Society 50():82 - 86 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2327 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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