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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2322| Título : | Effect of EGB761 supplementation on metallothionein I + II expression after 1-methyl-4-phenylpyridinium neurotoxicity |
| Creador: | Serrano García,Norma |
| Nivel de acceso: | Open access |
| Palabras clave : | Ginkgo biloba - uso terapéutico 1-Metil-4-fenilpiridinio - toxicidad Intoxicación por MPTP - terapia Enfermedad de Parkinson Secundaria - inducido químicamente Ginkgo biloba - therapeutic use 1-Methyl-4-phenylpyridinium - toxicity MPTP Poisoning - therapy Parkinson Disease, Secondary - chemically induced EGb761 Metallothionein I + II 1-methyl-4- phenylpyridinium Striatum |
| Descripción : | Metallothionein I+II(MTI+II) are neuroprotective proteins with an antioxidant action during 1-methyl-4-phenylpyridinium (MPP+) neurotoxicity, a model of Parkinson's disease. EGb761 has neuroprotective effects, via its antioxidant action. Here, we investigated whether in vivo pretreatment with EGb761 alters the expression of MT I+ II during MPP + neurotoxicicity. C-57 black mice were pretreated with EGb761 (10 mg/kg) daily for 17 days followed by administration of MPP+ (0.72 mg/kg) and were sacrificed 2 h, 24 h or 7 days later. Quantitative immunohistochemical evaluation of MT I + II expression was significantly elevated at 24 h in the striatum (21%) and substantia nigra (51%) in MPP + group. Pretreatment with EGb761 in MPP+ group regulated the MT I + II expression at 24 h to the normal levels in striatum and substantia nigra. Results suggest that EGb761-induced MT I + II expression is due to its protective action against MPP+ neurotoxicity. Copyright © 2007 by New Century Health Publishers, LLC. All rights of reproduction in any form reserved. |
| Colaborador(es) u otros Autores: | Ulises Rodríguez-Ortiz Julio Rojas-Castañeda Patricia Rojas |
| Fecha de publicación : | 2007 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Fuente: | Current Topics in Nutraceutical Research 5(2-3):83-92 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2322 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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