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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2321| Título : | Effect of dichlorvos on hepatic and pancreatic glucokinase activity and gene expression, and on insulin mRNA levels |
| Creador: | Romero Navarro G |
| Nivel de acceso: | Open access |
| Palabras clave : | Diclorvos - farmacología - ratas Regulación de la Expresión Génica - Genética - ratas Enzimológica -efectos de drogas - ratas Glucoquinasa - metabolismo - ratas Insecticidas - farmacología - ratas Insulina - biosíntesis - ratas Dosificación Letal Mediana - ratas Hígado - efectos de drogas - ratas Hígado - enzimología - ratas Páncreas - efectos de drogas - ratas Páncreas - enzimología - ratas ARN Mensajero - biosíntesis - ratas ratas Wistar Dichlorvos - pharmacology - rats Gene Expression Regulation - genetics - rats Enzymologic -drug effects - rats Glucokinase - metabolism - rats Insecticides - pharmacology - rats Insulin - biosynthesis - rats Lethal Dose 50 - rats Liver - drug effects - rats Liver - enzymology - rats Pancreas - drug effects - rats Pancreas - enzymology - rats RNA, Messenger -biosynthesis - Rats Rats, Wistar organofosforados plaguicidas diclorvos glucoquinasa Insulina - ratas Organophosphate Pesticides Dichlorvos Glucokinase Insulin - rats |
| Descripción : | Several studies have shown that organophosphate pesticides affect carbohydrate metabolism and produce hyperglycemia. It has been reported that exposure to the organophosphate pesticide dichlorvos affects glucose homeostasis and decreases liver glycogen content. Glucokinase (EC 2.7.1.1) is a tissue-specific enzyme expressed in liver and in pancreatic beta cells that plays a crucial role in glycogen synthesis and glucose homeostasis. In the present study we analyzed the effect of one or three days of dichlorvos administration [20 mg/kg body weight] on the activity and mRNA levels of hepatic and pancreatic glucokinase as well as on insulin mRNA abundance in the rat. We found that the pesticide affects pancreatic and hepatic glucokinase activity and expression differently. In the liver the pesticide decreased the enzyme activity; on the contrary glucokinase mRNA levels were increased. In contrast, pancreatic glucokinase activity as well as mRNA levels were not affected by the treatment. Insulin mRNA levels were not modified by dichlorvos administration. Our results suggest that the decreased activity of hepatic glucokinase may account for the adverse effects of dichlorvos on glucose metabolism. © 2005 Elsevier Inc. All rights reserved. |
| Colaborador(es) u otros Autores: | López-Aceves Tg Rojas-Ochoa A Fernández - Mejía C |
| Fecha de publicación : | 2006 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1016/j.lfs.2005.06.010 |
| Fuente: | Life Sciences 78(9):1015 - 1020 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2321 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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