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Título : Effect of dichlorvos on hepatic and pancreatic glucokinase activity and gene expression, and on insulin mRNA levels
Creador: Romero Navarro G
Nivel de acceso: Open access
Palabras clave : Diclorvos - farmacología - ratas
Regulación de la Expresión Génica - Genética - ratas
Enzimológica -efectos de drogas - ratas
Glucoquinasa - metabolismo - ratas
Insecticidas - farmacología - ratas
Insulina - biosíntesis - ratas
Dosificación Letal Mediana - ratas
Hígado - efectos de drogas - ratas
Hígado - enzimología - ratas
Páncreas - efectos de drogas - ratas
Páncreas - enzimología - ratas
ARN Mensajero - biosíntesis - ratas
ratas Wistar
Dichlorvos - pharmacology - rats
Gene Expression Regulation - genetics - rats
Enzymologic -drug effects - rats
Glucokinase - metabolism - rats
Insecticides - pharmacology - rats
Insulin - biosynthesis - rats
Lethal Dose 50 - rats
Liver - drug effects - rats
Liver - enzymology - rats
Pancreas - drug effects - rats
Pancreas - enzymology - rats
RNA, Messenger -biosynthesis - Rats
Rats, Wistar
organofosforados
plaguicidas
diclorvos
glucoquinasa
Insulina - ratas
Organophosphate
Pesticides
Dichlorvos
Glucokinase
Insulin - rats
Descripción : Several studies have shown that organophosphate pesticides affect carbohydrate metabolism and produce hyperglycemia. It has been reported that exposure to the organophosphate pesticide dichlorvos affects glucose homeostasis and decreases liver glycogen content. Glucokinase (EC 2.7.1.1) is a tissue-specific enzyme expressed in liver and in pancreatic beta cells that plays a crucial role in glycogen synthesis and glucose homeostasis. In the present study we analyzed the effect of one or three days of dichlorvos administration [20 mg/kg body weight] on the activity and mRNA levels of hepatic and pancreatic glucokinase as well as on insulin mRNA abundance in the rat. We found that the pesticide affects pancreatic and hepatic glucokinase activity and expression differently. In the liver the pesticide decreased the enzyme activity; on the contrary glucokinase mRNA levels were increased. In contrast, pancreatic glucokinase activity as well as mRNA levels were not affected by the treatment. Insulin mRNA levels were not modified by dichlorvos administration. Our results suggest that the decreased activity of hepatic glucokinase may account for the adverse effects of dichlorvos on glucose metabolism. © 2005 Elsevier Inc. All rights reserved.
Colaborador(es) u otros Autores: López-Aceves Tg
Rojas-Ochoa A
Fernández - Mejía C
Fecha de publicación : 2006
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1016/j.lfs.2005.06.010
Fuente: Life Sciences 78(9):1015 - 1020
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2321
Idioma: eng
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